Transient receptor potential vanilloid 1 receptors mediate acid-induced mucin secretion via Ca2+ influx in human airway epithelial cells

Journal of Biochemical and Molecular Toxicology
Hongmei YuJuliy M Perelman

Abstract

Mucin hypersecretion is a key pathological feature of inflammatory respiratory diseases. Previous studies have reported that acids (gastroesophageal reflux or environmental exposure) induce many respiratory symptoms and are implicated in the pathophysiology of obstructive airway diseases. To understand these mechanisms, we measured acid-induced mucin secretion in human bronchial epithelial cells. In the present study, acid induced inward currents of transient receptor potential vanilloid (TRPV)1 and mucin 5AC (MUC5AC) secretion dose dependently, which were inhibited by TRPV1 antagonist capsazepine in a concentration-dependent manner. TRPV1 agonist capsaicin mediated a concentration-dependent increase in TRPV1 inward currents and MUC5AC secretion. Furthermore, capsaicin enhanced acid-induced TRPV1 inward currents and MUC5AC secretion. Acid-induced Ca(2+) influx was prevented by capsazepine dose dependently and enhanced by capsaicin. Pretreatment only with capsaicin also increased the Ca(2+) concentration in a concentration-dependent manner. These data suggest that pharmacological inhibition of calcium-permeable TRPV1 receptors could be used to prevent acid-induced mucin secretion, thereby providing a potential mechanism to reduc...Continue Reading

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Citations

Oct 16, 2012·Respiratory Physiology & Neurobiology·Chunyi LiuJuliy M Perelman
Nov 30, 2013·British Journal of Pharmacology·M S GraceM G Belvisi
Jul 11, 2014·Current Opinion in Supportive and Palliative Care·Malgorzata KrajnikPiotr Sobanski
Nov 2, 2018·Journal of Biochemical and Molecular Toxicology·Rania A A SalamaEzz-El Din S Eldenshary
Apr 4, 2019·American Journal of Respiratory Cell and Molecular Biology·Aurelie PetitArnaud Bourdin
Apr 21, 2018·Allergy, Asthma & Immunology Research·Joon Young ChoiSook Young Lee
Nov 8, 2019·Pediatric Research·Giovanni Piedimonte, Terri J Harford
May 2, 2021·Environmental Science and Pollution Research International·Fengliu FengHaoran Jiao
Apr 1, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Terri J HarfordGiovanni Piedimonte

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