Transient responses of rabbit cerebral blood vessels to norepinephrine: correlation with intrinsic myogenic tone

Circulation Research
J A Bevan

Abstract

Transient contractile responses to norepinephrine (NE) of vascular segments from the rabbit vertebral, internal carotid, and basilar arteries rise to a peak within several seconds, and in the presence of the agonist, reverse rapidly, relaxing with a half-time of 15 +/- 3.2 seconds. In the basilar artery, peak contraction is approximately 25% of the maximum response mediated via the "alpha-like" adrenoreceptors and is elicited by NE 10(-7) M. Steady state contractions are seen with higher concentrations. Transient contractile responses are absent in segments from the brachiocephalic and external carotid arteries, and their incidence increases the more rostral along the length of the vertebral and internal carotid artery the origin of the segment studied. They were seen in all preparations of the intracranial vertebral and basilar arteries. There is a good correlation between the occurrence in any particular vascular segment of the transient contractile response and intrinsic tone as assessed by relaxation to papaverine (10(-6) M). The response was blocked by alpha-adrenergic receptor blocking agents and was not elicited by d-NE nor tetrahydrazoline or oxymetazoline. This response may be analogous to the first phase of the biphas...Continue Reading

References

Dec 10, 1985·European Journal of Pharmacology·I Laher, J A Bevan
Jan 1, 1994·Pharmacology & Therapeutics·P I Aaronson
Jul 20, 1983·The American Journal of Cardiology·R Ginsburg
Dec 1, 1981·Journal of Autonomic Pharmacology·T A McCalden
Jul 1, 1988·Journal of Neurosurgery·M TakayasuR G Dacey

Citations

Oct 1, 1978·Circulation Research·M J Purves
Jun 15, 1977·European Journal of Pharmacology·J D PickardA M Harper
Aug 1, 1977·The Journal of General Physiology·G DroogmansR Casteels
Dec 15, 1975·Experientia·T J LeeJ A Bevan
Jul 1, 1976·Circulation Research·T J LeeJ A Bevan
Apr 1, 1974·Acta Physiologica Scandinavica·J A Bevan, B Ljung
Jan 11, 1969·The American Journal of Physiology·B S GrimsonJ C Greenfield
Jun 1, 1971·Circulation Research·J A Bevan, J G Waterson
Oct 1, 1967·Circulation Research·C E RapelaA B Denison

Related Concepts

Pavatym
Papaverine
Oxymetazoline
Cerebrovascular System
Blood Vessel
Brain
Contraction (Finding)
Smooth Muscle
Muscle Relaxation Phase
Norepinephrine, (+, -)-Isomer

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.