Transient retardation in embryo growth in normal female mice made pregnant by males whose testes had been heated

Human Reproduction
B P SetchellM A Surani

Abstract

In three separate experiments, using three different strains of mice, when normal females were mated by males whose testes had been heated once to 42 degrees C for 20 min, the embryos at 10.5 days post-coitum were approximately 20% smaller than control embryos. In one experiment, the difference was still present, although proportionately less, at 15.5 and 18.5 days and, in another experiment, a difference could be seen in 11.5 and 13.5 day old embryos but not in 12.5, 14.5, 15.5 or 18.5 day old embryos. The frequency of mating and pregnancy rates were unaffected. In one experiment, the time available for mating was restricted to 4 h instead of overnight, without effect on the result. In another experiment, other males were heated for 30 min, and these showed a period of infertility from 10 to 32 days later, preceded and followed by the production of smaller than normal embryos; litter size was also reduced in the period after the return of fertility in these animals. The yolk sacs and the trophoblasts of the embryos sired by the heated males were also slightly smaller than those sired by the controls in the two experiments in which these were measured. The pattern of weight reduction is thus different from that seen in gynogene...Continue Reading

Citations

Jan 8, 2008·Molecular Human Reproduction·Catriona PaulPhilippa T K Saunders
Apr 9, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Catriona PaulPhilippa T K Saunders
Jan 19, 2010·Fertility and Sterility·Denny Sakkas, Juan G Alvarez
Sep 26, 2012·Cellular and Molecular Life Sciences : CMLS·Byunghyuk KimKunsoo Rhee
Nov 11, 2008·Theriogenology·K M CammackW R Lamberson
Apr 17, 2007·Fertility and Sterility·Martin SergerieLouis Bujan
Sep 12, 2006·Theriogenology·K M CammackW R Lamberson
Apr 2, 2015·Chemosphere·Ana F FerreiraArmindo dos Santos Rodrigues
Dec 3, 2011·Biology of Reproduction·Brian P Setchell
Feb 16, 2019·Molecular Reproduction and Development·Raffaele Boni
Aug 13, 2011·Reproductive Medicine and Biology·Masashi Takahashi
Oct 20, 2017·Reproductive Biology and Endocrinology : RB&E·J Isoler-AlcarazJ Del Mazo
Dec 15, 2018·Andrologia·Noushin MahdivandFatemeh Rahmani
Aug 26, 2006·Reproduction, Fertility, and Development·J YaeramS Maddocks

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