Transient somatostatin-immunoreactive ganglion cells in the developing rat retina

Brain Research. Developmental Brain Research
G FontanesiP Bagnoli

Abstract

The peptide somatostatin (SRIF) is likely to play important roles in neuronal differentiation and maturation. In the mammalian retina, it is reported to be expressed by populations of amacrine and/or displaced amacrine cells and, in some species, by some ganglion cells. Previous studies have shown that in the rat retina the maturation of somatostatinergic systems encompasses late prenatal and early postnatal periods, suggesting a role of SRIF in maturative events of the retina. SRIF-expressing ganglion cells have not been reported in the rat retina at any developmental age. In the present study, we re-evaluated the postnatal development of SRIF-containing neurons of the rat retina focusing on the analysis of SRIF-containing cells in the ganglion cell layer (GCL), to test the possibility that SRIF is expressed by some ganglion cells during development. To this aim we combined immunocytochemical staining of SRIF-positive neurons with retrograde tracing of ganglion cell bodies through Fluoro-Gold injections into the superior colliculus. Double-labelling experiments revealed the presence of SRIF-containing ganglion cells at postnatal day (PND) 10. They accounted for 14% of the total SRIF-containing cells in the GCL. Such double-lab...Continue Reading

References

Mar 8, 1992·The Journal of Comparative Neurology·C A White, L M Chalupa
Jun 19, 1992·Brain Research. Developmental Brain Research·D M Ferriero
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B GonzalezH Vaudry
Feb 1, 1991·The Journal of Comparative Neurology·C A White, L M Chalupa
Mar 1, 1990·The Journal of Comparative Neurology·C A WhiteN C Brecha
Dec 1, 1990·Brain Research. Developmental Brain Research·D M FerrieroS M Sagar
Sep 25, 1989·Neuroscience Letters·J MitrofanisJ M Provis
Jul 22, 1982·Brain Research·S M SagarJ B Martin
Jan 1, 1982·Histochemistry·K TornqvistB Ehinger
Aug 1, 1983·Brain Research·R Linden, V H Perry
Sep 20, 1983·The Journal of Comparative Neurology·V H PerryR Linden
Mar 1, 1982·Brain Research·R A PottsM R Bennett
Aug 28, 1995·Brain Research. Developmental Brain Research·T Taniwaki, J P Schwartz
Jan 1, 1996·The European Journal of Neuroscience·R Engelmann, L Peichl
Dec 1, 1995·Cellular and Molecular Neurobiology·T Reisine
Sep 1, 1996·Progress in Neurobiology·M SchindlerP C Emson

❮ Previous
Next ❯

Citations

May 4, 2002·Brain Research·Rosella CristianiPaola Bagnoli
Oct 6, 2000·Brain Research. Developmental Brain Research·G FontanesiP Bagnoli
May 18, 2001·Brain Research. Developmental Brain Research·Z XiangZ Kang
Feb 5, 2008·Molecular and Cellular Endocrinology·Davide CerviaPaola Bagnoli
Sep 19, 2012·Developmental Neuroscience·Daniel BodmerVesna Radojevic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.