Transient upregulation of postsynaptic IP3-gated Ca release underlies short-term potentiation of metabotropic glutamate receptor 1 signaling in cerebellar Purkinje cells.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sang Jeong KimDavid J Linden

Abstract

Synaptic plasticity lasting approximately 100 s has been suggested to function as a temporary buffer for neural information. One example of this was reported by Batchelor and Garthwaite (1997), who found that a slow metabotropic glutamate receptor 1 (mGluR1)-evoked EPSP produced by burst stimulation of cerebellar parallel fiber-Purkinje cell synapses could be potentiated by a conditioning stimulus consisting of prior activation of climbing fiber synapses (or injection of depolarizing current) with a delay of up to 90 s. What is the molecular basis of the signal that spans this temporal gap? Here, we show that mGluR1-evoked slow EPSCs evoked by parallel fiber burst test stimuli show a similar form of short-term potentiation (mGluR1-STP) and that this phenomenon is also observed when parallel fiber bursts are replaced by pressure pulses of an exogenous mGluR1 agonist. Ca imaging experiments revealed that cytosolic Ca levels returned to baseline within several seconds after conditioning depolarization, indicating that this cannot underlie mGluR1-STP. To test the hypothesis that transient upregulation of inositol-1,4,5-trisphosphate (IP(3))-gated Ca release underlies this phenomenon, we used local photolytic uncaging of IP(3) to de...Continue Reading

References

Jun 4, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J HartmannA Konnerth
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yohei OkuboMasamitsu Iino
Jul 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takashi MaejimaMasanobu Kano
Mar 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoshinobu KawamuraMasanobu Kano

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Citations

May 9, 2012·Nature Neuroscience·Jia-Hua HuPaul F Worley
Feb 26, 2011·The International Journal of Neuroscience·Dimitrios MichmizosStavros Baloyannis
Dec 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Liang ZhouYing Shen
Jul 29, 2009·Neural Networks : the Official Journal of the International Neural Network Society·Reinoud Maex, Volker Steuber
May 6, 2011·Nature Reviews. Neuroscience·Chris I De ZeeuwSebastiaan K Koekkoek
Apr 9, 2014·The Journal of Physiology·John G PartridgeStefano Vicini
Sep 8, 2010·Mathematical Biosciences·Weijiu LiuJingvoon Chen

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