PMID: 10406026Jul 16, 1999

Transient vasodilatory effects of adrenomedullin on cerebral parenchymal microvessels in cats

Neuroscience Letters
M TakaoY Fukuuchi

Abstract

We studied the effects of adrenomedullin, structural homology of calcitonin gene-related peptide (CGRP), on the cerebral parenchymal microvessels in cats by our photoelectric method. Adrenomedullin significantly increased cerebral blood volume (CBV) at 0.5 and 1 min after intracarotid injection (0.01-1 nmol/kg, maximum; +0.71 vol% for 0.1 nmol/kg adrenomedullin). Adrenomedullin antagonist, adrenomedullin22-62 (0.01-10 nmol/kg), caused no significant changes in CBV and mean arterial blood pressure. Preinjection of 10 nmol/kg adrenomedullin22-52 blocked the vasodilatory effect of 0.01 nmol/kg adrenomedullin (P < 0.05). Pretreatment of 1 nmol/kg CGRP8-37, which has antagonistic activity against CGRP, also inhibited the vasodilatation of adrenomedullin. The degree of CBV reduction after adrenomedullin22-52 injection was greater than that after CGRP8-37 injection. Adrenomedullin has no major role in the maintenance of resting tone of intracerebral parenchymal vessels. Intravascularly administered adrenomedullin dilates cortical microvessels mainly through the specific adrenomedullin receptor.

References

Jan 5, 2002·Peptides·Bela KisYoichi Ueta
Mar 13, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Bela KisYoichi Ueta
Apr 27, 2000·Endocrine Reviews·J P HinsonD M Smith

Citations

Oct 27, 1995·The Journal of Biological Chemistry·S KapasA J Clark
Sep 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R R WhitesellJ M May
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·W I RosenblumG H Nelson
Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A DoganJ Yoshida
Jan 1, 1997·Stroke; a Journal of Cerebral Circulation·M G LangD D Heistad
Jul 9, 1997·European Journal of Pharmacology·Y MoriH Hidaka

Related Concepts

CALCA gene
Calcitonin gene-related peptide (8-37)
Calcitonin Gene-Related Peptide
CALCA wt Allele
HCGRP (8-37)
Adrenomedullin
Diastolic Blood Pressure
Antagonist Muscle Action
Brain
ADM gene

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