PMID: 9420289Jan 7, 1998Paper

Transient viral DNA replication and repression of viral transcription are supported by the C-terminal domain of the bovine papillomavirus type 1 E1 protein

Journal of Virology
M C Ferran, Alison A McBride

Abstract

The bovine papillomavirus type 1 E1 protein is important for viral DNA replication and transcriptional repression. It has been proposed that the full-length E1 protein consists of a small N-terminal and a larger C-terminal domain. In this study, it is shown that an E1 polypeptide containing residues 132 to 605 (which represents the C-terminal domain) is able to support transient viral DNA replication, although at a level lower than that supported by the wild-type protein. This domain can also repress E2-mediated transactivation from the P89 promoter as well as the wild-type E1 protein can.

References

Oct 1, 1991·Journal of Virology·V G Wilson, J Ludes-Meyers
Jan 1, 1991·Cold Spring Harbor Symposia on Quantitative Biology·L YangM Botchan
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T GrussenmeyerG Walter
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y C YangP M Howley
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·O V GjørupB S Schaffhausen
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·M LuskyY S Seo
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y S SeoJ Hurwitz
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E UstavA Stenlund
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L YangM Botchan

❮ Previous
Next ❯

Citations

Sep 20, 2002·The Journal of Biological Chemistry·Samuel Y HouCheng-Ming Chiang
Jul 19, 2000·The Journal of General Virology·G D McShan, V G Wilson
Jul 8, 2011·Journal of Virology·Nozomi SakakibaraAlison A McBride
Mar 10, 2006·Virology Journal·Michael R LentzNancy Elkhoury
Jun 24, 2008·Critical Reviews in Biochemistry and Molecular Biology·Karl E Duderstadt, James M Berger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.