Transistor array with an organotypic brain slice: field potential records and synaptic currents

The European Journal of Neuroscience
Brigitte Besl, P Fromherz

Abstract

Linear transistor arrays on a silicon chip were used to map evoked extracellular field potentials in organotypic brain slices of rat hippocampus. The shape and amplitude of the transients were similar to those from records with micropipette electrodes. The spatial resolution was 21 and 4.6 microm. The sampled profile of the field potential showed a wide and shallow trough of transients in the stratum radiatum and a narrow but higher ridge in the stratum pyramidale. Due to the high resolution, the profile could be interpreted quantitatively in terms of synaptic currents. Transistor chips may become a novel tool for neurophysiological and pharmacological studies in brain slices.

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Citations

Feb 14, 2012·European Biophysics Journal : EBJ·Pavel M BulaiSergey N Cherenkevich
Oct 13, 2009·The European Physical Journal. E, Soft Matter·P ArianoE Vittone
Nov 6, 2008·Bio Systems·R M R PizziW Baer
Apr 20, 2004·The European Journal of Neuroscience·Michael Hutzler, Peter Fromherz
Mar 13, 2008·The European Journal of Neuroscience·Christian Stangl, Peter Fromherz
Jul 18, 2006·Bio Systems·R PizziA Vescovi
Jan 23, 2015·Frontiers in Neuroscience·Marie Engelene J ObienUrs Frey
Dec 21, 2016·Journal of Molecular Recognition : JMR·Martin PeslVladimir Rotrekl
Jun 16, 2015·PloS One·Vassilis GeorgiadisThomas R Jackson
Sep 14, 2019·Advanced Materials·Amy E RochfordDamiano G Barone
Jun 7, 2014·Chemical Reviews·Qingjun LiuPing Wang

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