Abstract
Background and objective: Two endothelin receptor antagonists (ETRAs), bosentan and ambrisentan, are approved for patients with pulmonary arterial hypertension (PAH). However, there is little information about the transition strategy between these two ETRAs. We aimed to evaluate the safety and efficacy from ambrisentan to bosentan. Methods: Twenty PAH patients were enrolled into the single-center, open-labelled prospective study. Echocardiogram, WHO functional class (WHO-FC), 6-minute walking distance (6MWD), right heart catheterization, and hemotology were collected. After receiving oral 5 mg ambrisentan daily initially for one year, the patients were divided into two arms: eight patients switched to bosentan, while the remaining 12 patients continued ambrisentan. Characteristics at baseline, 1-and 2-year follow-up points were compared. There were no significant differences in echocardiogram, WHO-FC, hemodynamics, demographics and liver function at baseline, 1-and 2-year points in both arms. 6MWD in bosentan group was significantly shorter at baseline. But there were no significant differences of 6MWD at 1- and 2-year points. It is safe for stable PAH patients to transition from ambrisentan to bosentan without hemodynamic or h...Continue Reading
References
Mar 15, 1991·Annals of Internal Medicine·D J StewartD Langleben
Jan 19, 1995·The American Journal of Cardiology·L J Rubin
Jun 17, 1993·The New England Journal of Medicine·A GiaidD J Stewart
Aug 23, 2000·Circulation·N NagayaK Kangawa
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
May 14, 2005·Vascular Pharmacology·Adaani E FrostR J Barst
Nov 18, 2005·The New England Journal of Medicine·Nazzareno GalièUNKNOWN Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group
May 11, 2006·Chest·Anna FijalkowskaMonika Szturmowicz
Jun 14, 2008·The European Respiratory Journal·M A PuhanH J Schünemann
Sep 25, 2008·Chest·Michael D McGoonLewis J Rubin
Jan 22, 2009·European Heart Journal·Nazzareno GalièAngelo Branzi
Dec 25, 2009·The European Respiratory Journal·T ThenappanM Gomberg-Maitland
Jun 30, 2010·Circulation·Raymond L BenzaMichael D McGoon
Dec 7, 2010·American Journal of Respiratory and Critical Care Medicine·Roland M du BoisTalmadge E King
Apr 7, 2011·Vascular Health and Risk Management·Zeenat Safdar
Jul 24, 2012·The Canadian Journal of Cardiology·Benjamin FoxLyda Lesenko
Sep 19, 2012·The Canadian Journal of Cardiology·Nancy Luo, John J Ryan
Mar 25, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Neeraj DhaunDavid J Webb
Mar 21, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Meghan AversaJohn Granton
Oct 6, 2015·Research in Cardiovascular Medicine·Ahmad AminHosnolah Sadeghi
Nov 3, 2015·Echocardiography·Nicole PristeraBrian D Hoit
Citations
Jul 31, 2020·International Heart Journal·Hisataka MakiIssei Komuro
Jun 4, 2021·International Journal of General Medicine·Jingyuan ChenJiang Li
Feb 19, 2019·Heart, Lung & Circulation·Kazuhiro KurodaHiroshi Ito