Transition from fetal to neonatal circulation: Modeling the effect of umbilical cord clamping

Journal of Biomechanics
Mehmet B YigitKerem Pekkan

Abstract

Hemodynamics of the fetal to neonatal transition are orchestrated through complex physiological changes and results in cardiovascular adaptation to the adult biventricular circulation. Clinical practice during this critical period can influence vital organ physiology for normal newborns, premature babies and congenital heart defect patients. Particularly, the timing of the cord clamping procedure, immediate (ICC) vs. delayed cord clamping (DCC), is hypothesized to be an important factor for the transitory fetal hemodynamics. The clinical need for a quantitative understanding of this physiology motivated the development of a lumped parameter model (LPM) of the fetal cardio-respiratory system covering the late-gestation to neonatal period. The LPM was validated with in vivo clinical data and then used to predict the effects of cord clamping procedures on hemodynamics and vital gases. Clinical time-dependent resistance functions to simulate the vascular changes were introduced. For DCC, placental transfusion (31.3 ml) increased neonatal blood volume by 11.7%. This increased blood volume is reflected in an increase in preload pressures by ~20% compared to ICC, which in turn increased the cardiac output (CO) by 20% (COICC=993 ml/min...Continue Reading

References

Jan 1, 1986·Circulation·K L ReedL Shenker
Nov 1, 1986·The Journal of Physiology·J C McGrathM J Whittle
Jan 1, 1986·Computers in Biology and Medicine·C S Peskin, C Tu
Mar 1, 1973·Canadian Journal of Physiology and Pharmacology·F Coceani, P M Olley
Feb 1, 1994·American Journal of Obstetrics and Gynecology·Y VilleK H Nicolaides
Sep 25, 2001·American Journal of Obstetrics and Gynecology·F LackmanB Richardson
Mar 26, 2002·The Journal of Perinatal & Neonatal Nursing·Judith S Mercer, Rebecca L Skovgaard
Sep 1, 1994·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K HecherK Nicolaides
Sep 1, 1963·Acta Paediatrica·R USHERJ LIND
Sep 1, 1964·The Journal of Pediatrics·G C EMMANOUILIDESF H ADAMS
Dec 3, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kerem PekkanAjit P Yoganathan
Jun 2, 2006·The Journal of Pediatrics·Ola Didrik Saugstad
Jul 11, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T KiserudS Rasmussen
Jul 18, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·F S MolinaK H Nicolaides
Oct 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Kartik S SundareswaranAjit P Yoganathan
Jun 26, 2009·Annals of Biomedical Engineering·Jan-Willem LankhaarNico Westerhof
Aug 14, 2009·The Journal of Physiology·Kelly J CrossleyStuart B Hooper
Oct 8, 2009·Pediatric Research·Carla D Sá-CoutoPedro M Sá-Couto
May 5, 2010·Pediatrics·Jennifer A DawsonColin J Morley
Oct 21, 2010·Physiological Reviews·Yuansheng Gao, J Usha Raj
Feb 15, 2012·Pediatrics·Ross SommersJudith Mercer
Feb 15, 2013·Current Opinion in Pediatrics·Tonse N K Raju
Sep 24, 2013·Seminars in Fetal & Neonatal Medicine·Susan Niermeyer, Sithembiso Velaphi
Apr 2, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·Marrit SmitArjan B te Pas
Nov 13, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·I BoereA B Te Pas

❮ Previous
Next ❯

Citations

Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Angie C JelinRonald Clyman
Nov 26, 2015·Neural Regeneration Research·Christopher LawtonCesar V Borlongan
Jan 11, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Kelly KuoMelissa March
Oct 25, 2016·The Journal of Perinatal & Neonatal Nursing·Jessica ChapmanJulie Reid
Jan 1, 2015·Maternal Health, Neonatology and Perinatology·Anup C KatheriaNeil N Finer
Dec 19, 2018·Antioxidants·Iván MillánMáximo Vento
Apr 24, 2019·Maternal Health, Neonatology and Perinatology·Berk YigitKerem Pekkan
Oct 12, 2020·International Journal of Impotence Research·Canberk YildirimEge Can Serefoglu
Mar 19, 2021·Pediatric Research·Anneloes G MunnekeTammo Delhaas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.