Transition from intravenous treprostinil to enteral selexipag in an infant with pulmonary arterial hypertension

Cardiology in the Young
Rachel KooMatthew J Bock

Abstract

Selexipag is an enteral, selective prostacyclin IP receptor agonist approved for pulmonary hypertension in adults. There are few reports of its use in children and none in infants. We report the first transition of an infant (11.5 months, 8.6 kg) from intravenous treprostinil (40 ng/kg/minute) to enteral selexipag (400 mcg twice daily) with a good response and no adverse effects.

References

Jul 10, 2014·Pulmonary Circulation·Chelsey M McIntyreE Zachary Ramsey
Dec 25, 2015·The New England Journal of Medicine·Olivier SitbonP G Williams
Jul 14, 2017·Pediatric Cardiology·Roberto GallottiJuan Alejos

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Citations

Oct 2, 2020·Pediatric Pulmonology·Charissa W Kam, Fadel E Ruiz
Nov 3, 2020·Current Opinion in Cardiology·Dunbar Ivy, Benjamin S Frank
Mar 7, 2021·Pediatric Research·Catheline HocqUNKNOWN from the European Society for Pediatric Research
Jul 10, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Elizabeth ColglazierJeffrey R Fineman

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