Transition from pemphigus foliaceus to pemphigus vulgaris: case report with literature review.

Yonsei Medical Journal
Sang Gun ParkMin-Geol Lee

Abstract

The transition between the main subtypes of pemphigus, pemphigus vulgaris (PV), and pemphigus foliaceus (PF) has rarely been reported. Moreover, the development of PV in a patient with PF is much more unusual than that of PF in a patient with PV. We report a 48-year-old man who presented with cutaneous lesions showing the typical clinical and histological features of PF. Five years later, his skin lesions became extensive and he developed oral erosions. His condition did not respond well to steroids and azathioprine. Histological examination of a vesicle disclosed suprabasal acantholysis in contrast to the subcorneal acantholysis discovered upon initial histological evaluation. Indirect immunofluorescence revealed IgG antikeratinocyte cell surface antibodies at a titer of 1:640. The titer was 1:160 at initial diagnosis. Upon immunoblotting, the patient's serum reacted with 130 kiloDalton (kDa) and 160 kDa proteins, suggesting desmoglein (Dsg) 3 and 1, respectively. We herein report an unusual case of PV that developed from PF during the disease's flare-up.

References

Nov 1, 1991·Journal of the American Academy of Dermatology·K IwatsukiM Yamada
Jun 1, 1991·Archives of Dermatology·T HashimotoT Nishikawa
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Citations

Jan 22, 2010·Indian Journal of Pathology & Microbiology·Fauziya SabirS Sohail Amin
Dec 10, 2013·Annales de dermatologie et de vénéréologie·C Lévy-SitbonP Bernard
Dec 1, 2006·Autoimmunity·Sergei A Grando
Jun 18, 2011·Clinics in Dermatology·Jaka Radoš
Oct 26, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·M DaneshpazhoohY Dowlati
Jul 20, 2011·The Journal of Dermatology·Sajad A DarAkhil C Banerjea
Jan 18, 2018·Head and Neck Pathology·Alexandra C PerksAnne M Hegarty
May 3, 2018·Frontiers in Immunology·Dario Didona, Giovanni Di Zenzo
Nov 8, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·T ItoS Shimizu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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