Transition Metal-Catalyzed Enantioselective C-H Functionalization via Chiral Transient Directing Group Strategy

Angewandte Chemie
Gang LiaoBing-Feng Shi

Abstract

Transition metal-catalyzed enantioselective functionalization of C-H bond, the most abundant functionality in organic molecules, has emerged as an expedient synthetic approach to streamline the synthesis of complex chiral molecules. Despite significant progress, traditional directing group-enabled strategy requires additional steps for the installation and removal of directing groups from the target molecule. The recent developed asymmetric C-H functionalization using chiral transient directing groups ( c TDGs) offers a promising alternative that can circumvent this obstacle and therefore simplify the process. In this minireview, we briefly discuss the advent and recent advances of this emerging concept, with an emphasis on discussing the creation of various stereogenic centers and the developments of c TDGs. Applications in natural product synthesis and ligand derivatizations are also discussed. We hope this minireview will highlight the great potential of this strategy and help to inspire further endeavors.

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Citations

Nov 19, 2020·ChemSusChem·Bogdan Y Karlinskii, Valentine P Ananikov
Feb 10, 2021·Chemistry : a European Journal·Liam S Fitzgerald, Miriam L O'Duill
Apr 20, 2021·Organic & Biomolecular Chemistry· SumitUpendra Sharma
Apr 9, 2021·Chemistry : a European Journal·Guanzhao WuGuigen Li
Jul 13, 2021·Frontiers in Chemistry·Kaijin LinHonggui Lin
Jul 17, 2021·Organic Letters·Michael Kohr, Uli Kazmaier
Jul 22, 2021·Chemistry : a European Journal·Clément JacobGwilherm Evano
Sep 18, 2021·Chemical Communications : Chem Comm·Maha FatthallaSamir Messaoudi
Sep 25, 2021·Organic Letters·Shuai Yang, Yanghui Zhang
Oct 26, 2021·Chemical Communications : Chem Comm·Sumeet Ranjan SahooDebabrata Maiti
Oct 28, 2021·Organic & Biomolecular Chemistry·Javeed Ahmad TaliRavi Shankar
Nov 9, 2021·Journal of the American Chemical Society·Yan-Hua LiuBing-Feng Shi

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