Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3 )Me2 -Containing Heteroarenes

Organic Letters
Shuai LiuXiu-Hua Xu

Abstract

The direct synthesis of C(CF3)Me2-substituted heteroarenes by decarboxylative 1,1-dimethyltrifluoroethylation of heteroarenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid is reported. This method does not need the transition-metal catalyst, and the base is crucial for this reaction. A series of previously unknown C(CF3)Me2-containing heteroarenes were obtained in high yields and have potential applications in the drug discovery process.

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Citations

Jun 4, 2019·Organic & Biomolecular Chemistry·Qiumin KeXiangmei Wu
Aug 14, 2020·Organic & Biomolecular Chemistry·Hangcheng NiFei Zhao
Sep 24, 2020·Chemical Communications : Chem Comm·Hai-Yan SuFeng-Ling Qing

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