Transition-Metal-Free Synthesis of Biarylmethanes from Aryl Iodides and Benzylic Ketones

Chemistry : a European Journal
Martin Pichette DrapeauMarc Taillefer

Abstract

An original metal-free procedure for the synthesis of biarylmethanes is disclosed herein. The reactions occur with high selectivity starting from aryl iodides and benzylic ketones in the presence of superbasic media (CsOH/DMSO). This procedure allows a straightforward access to a wide range of biarylmethane derivatives substituted with electron-withdrawing and -donating substituents.

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Citations

Jan 9, 2020·The Journal of Organic Chemistry·Samantha RoheLouis Barriault

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