Transition Metal Ion-Mediated Tyrosine-Based Short-Peptide Amphiphile Nanostructures Inhibit Bacterial Growth

Chembiochem : a European Journal of Chemical Biology
Ramesh SinghKhashti Ballabh Joshi

Abstract

We report the design and synthesis of a biocompatible small-peptide-based compound for the controlled and targeted delivery of encapsulated bioactive metal ions through transformation of the internal nanostructures of its complexes. A tyrosine-based short-peptide amphiphile (sPA) was synthesized and observed to self-assemble into β-sheet-like secondary structures. The self-assembly of the designed sPA was modulated by application of different bioactive transition-metal ions, as was confirmed by spectroscopic and microscopic techniques. These bioactive metal-ion-conjugated sPA hybrid structures were further used to develop antibacterial materials. As a result of the excellent antibacterial activity of zinc ions the growth of clinically relevant bacteria such as Escherichia coli was inhibited in the presence of zinc⋅sPA conjugate. Bacterial testing demonstrated that, due to high biocompatibility with bacterial cells, the designed sPA acted as a metal ion delivery agent and might therefore show great potential in locally addressing bacterial infections.

References

Mar 1, 1981·Journal of Clinical Microbiology·S HalebianR D Rolfe
Feb 26, 2000·Science·J S MartinezA Butler
May 29, 2000·Photochemistry and Photobiology·J M GlandièresB Alpert
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey D HartgerinkSamuel I Stupp
Nov 7, 2002·Journal of the American Chemical Society·Guofeng XuAlison Butler
Aug 1, 1989·Applied and Environmental Microbiology·Ala Abbas, Clive Edwards
Jun 1, 2006·Journal of the American Chemical Society·Sergey E ParamonovJeffrey D Hartgerink
Oct 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Arik MakovitzkiYechiel Shai
Dec 13, 2006·Biopolymers·Antonella AccardoGiancarlo Morelli
Oct 2, 2007·Journal of Bacteriology·Guennadi SezonovRichard D'Ari
Nov 8, 2007·Journal of the American Chemical Society·Daphne A SalickJoel P Schneider
Dec 11, 2007·Journal of the American Chemical Society·Steven N Dublin, Vincent P Conticello
Apr 30, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Tate OwenAlison Butler
Jul 19, 2008·The Biochemical Journal·Graham S BaldwinRaymond S Norton
Sep 1, 2009·Chemical Reviews·Kathryn L Haas, Katherine J Franz
May 26, 2010·Chemical Society Reviews·Xiubo ZhaoJian R Lu
Oct 30, 2010·Chemical Communications : Chem Comm·Valeria CastellettoDganit Danino
Mar 16, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Krishna R RaghupathiAdhar C Manna
Feb 2, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Heather M Baker, Edward N Baker
Oct 30, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Angela ChemelliOtto Glatter
Dec 15, 2012·Journal of Colloid and Interface Science·Xavier MuletCalum J Drummond
Apr 5, 2013·Physical Chemistry Chemical Physics : PCCP·Wei DengEwa M Goldys
Apr 15, 2014·Journal of Peptide Science : an Official Publication of the European Peptide Society·Ashkan DehsorkhiIan W Hamley
May 16, 2014·Journal of the American Chemical Society·Nilofar FaruquiMaxim G Ryadnov
Jan 15, 2015·Biochemistry·Michelle P KemAlison Butler
May 9, 2015·Chemical Society Reviews·Rongfeng ZouHe Tian
May 13, 2015·Physical Chemistry Chemical Physics : PCCP·Jascindra RaviMaxim G Ryadnov
Jun 13, 2015·Journal of Colloid and Interface Science·Narendra Kumar MishraSandeep Verma
Jan 8, 2016·International Journal of Molecular Sciences·Wolfgang Maret
Aug 20, 2016·The Journal of Physical Chemistry Letters·Mark GontsarikStefan Salentinig

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Materials Science & Engineering. C, Materials for Biological Applications
Jun LinYiwang Chen
Journal of Colloid and Interface Science
Narendra Kumar MishraSandeep Verma
© 2022 Meta ULC. All rights reserved