Transition Metal-Mediated DNA Adsorption on Polydopamine Nanoparticles.

Langmuir : the ACS Journal of Surfaces and Colloids
Mohamad Zandieh, Juewen Liu

Abstract

Polydopamine (PDA) is a widely used universal coating for a broad range of materials. Interfacing PDA with various biomolecules, such as DNA, is critical for applications such as sensing, intracellular delivery, and material fabrication. Because of the negative surface charge of PDA at neutral pH, electrostatic repulsion exists between PDA and DNA. In previous studies, modified DNA or low pH was used to overcome this repulsion for DNA adsorption. More recently, divalent Ca2+ was found to bridge DNA and PDA. Herein, we studied four transition metals (Mn2+, Co2+, Zn2+, and Ni2+) and compared their efficiencies with Ca2+ for promoting DNA adsorption. These transition metals induced a more efficient and tighter DNA binding compared to Ca2+. In all these cases, the DNA phosphate backbone played a dominant role in adsorption, although DNA bases might also interact with strong binding metals such as Ni2+. Moreover, when the adsorption affinity was stronger, sensing was more selective to complementary DNA. Finally, aging of PDA appeared to be detrimental for DNA adsorption, which could be due to further oxidation of PDA. We showed that using Zn2+ or Ni2+ could considerably relieve the aging effect, while storing PDA at 4 °C could slow ...Continue Reading

References

Oct 20, 2007·Science·Haeshin LeePhillip B Messersmith
Sep 16, 2009·Accounts of Chemical Research·Xiaohong Fang, Weihong Tan
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hongbo ZengJ Herbert Waite
Feb 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Niels Holten-AndersenJ Herbert Waite
Oct 26, 2011·Nanoscale·Martin E LyngeBrigitte Städler
Jun 29, 2012·Physical Chemistry Chemical Physics : PCCP·Juewen Liu
Aug 2, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Jennifer B WoodRobert M Corn
Oct 19, 2013·Analytical Chemistry·Gabriel LogetRobert M Corn
Dec 24, 2013·Inorganic Chemistry·Yu Xiang, Yi Lu
May 23, 2015·Journal of the American Chemical Society·Chun Kit K ChoiLiming Bian
Nov 4, 2015·Chemical Communications : Chem Comm·Daoqing FanErkang Wang
Jun 10, 2017·Chemical Reviews·Wenhu ZhouJuewen Liu
Aug 15, 2017·Accounts of Chemical Research·Meng LiuYingfu Li
Oct 13, 2017·Small·Zhao WangNathan C Gianneschi
Jul 13, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Lei ChenJuewen Liu
Sep 4, 2018·Frontiers in Bioengineering and Biotechnology·Vincent Ball
Jul 3, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Zhicheng HuangJuewen Liu

❮ Previous
Next ❯

Citations

Feb 18, 2021·Chemical Society Reviews·Di WuJesse V Jokerst
Jul 27, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Mohamad Zandieh, Juewen Liu
Nov 18, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Mohamad Zandieh, Juewen Liu
Sep 4, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Mehal P KushalkarJuewen Liu
Jan 14, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Zhen WangJuewen Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pennsylvania Dental Journal
Bruce R Terry
Pennsylvania Dental Journal
Bernie Dishler
Healthcare Informatics : the Business Magazine for Information and Communication Systems
J Sutherland
Advance for Nurse Practitioners
Alice M Teall
PDA Journal of Pharmaceutical Science and Technology
Lee Kirsch
© 2021 Meta ULC. All rights reserved