Transition of metabolic phenotypes and risk of subclinical atherosclerosis according to BMI: a prospective study.

Diabetologia
Lin LinYuhong Chen

Abstract

The cardiometabolic risk associated with metabolically healthy obesity (MHO) remains the subject of debate. It is unclear whether MHO is a transient condition that affects subclinical atherosclerosis risk. In this study, we aimed to investigate the association of MHO and its transition over time with incident subclinical atherosclerosis. A prospective study was conducted with 6220 Chinese adults who were free of cardiovascular disease (CVD) at baseline. Obesity was defined as BMI ≥25.0 kg/m2. Metabolic health was defined as an individual having fewer than two of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP ATP III) criteria for components of the metabolic syndrome (excluding waist circumference). Subclinical atherosclerosis was measured by brachial-ankle pulse wave velocity, pulse pressure and albuminuria, separately or combined. Participants were cross-classified by BMI categories and by metabolic health status and its transition during follow-up. Inverse probability weighted logistic regression models were used to estimate ORs and 95% CIs for subclinical atherosclerosis. The MHO phenotype accounted for 16.3% of the total population an...Continue Reading

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Citations

Aug 21, 2020·Endocrinology and Metabolism·Norbert Stefan
Jan 8, 2021·Journal of Translational Medicine·Jéssica D SchroderLeandro Henrique Manfredi
Aug 13, 2021·International Journal of Clinical Practice·Asena Gökçay CanpolatDemet Çorapçıoğlu
Aug 28, 2021·The Journal of Clinical Endocrinology and Metabolism·Chaojie YeTiange Wang

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