Transitional B cells in humans: characterization and insight from B lymphocyte reconstitution after hematopoietic stem cell transplantation

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Aude Marie-CardineSerge Jacquot

Abstract

Transitional B cells have been recently identified in human peripheral blood. However, their precise role in human B cell differentiation has not been established. Therefore, besides characterizing them further in the blood of healthy adults and children and cord blood, we used the immune reconstitution after hematopoietic stem cell transplantation (HSCT) model to define their role in human B cell development. Human transitional B cells are reliably identified as CD19(+) CD24(high) CD38(high) lymphocytes and represent approximately 4% of B cells in healthy adult peripheral blood. In contrast, they are abundant in cord blood (near 50% of B cells) and their percentage progressively decreases during infancy. Similarly, after HSCT, all B cells first appearing in peripheral blood are transitional B cells; afterwards, the transitional B cell percentage progressively decreases while the mature naïve B cell proportion rises. Our results now formally demonstrate that transitional B cells are necessary developmental intermediates for human mature B cell generation.

References

Jun 1, 1995·The Journal of Experimental Medicine·R CarsettiM C Lamers
Nov 6, 1998·The Journal of Experimental Medicine·S G TangyeJ E de Vries
Nov 21, 2000·The Journal of Experimental Medicine·M BattenF Mackay
Aug 16, 2003·Science·Hedda WardemannMichel C Nussenzweig
Feb 14, 2004·Immunological Reviews·Rita CarsettiHedda Wardmann
Mar 2, 2005·The Journal of Experimental Medicine·Sergey YurasovMichel C Nussenzweig
May 18, 2005·The Journal of Experimental Medicine·Jonathan SamuelsEric Meffre
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Angela MalaspinaAnthony S Fauci
Mar 23, 2006·Blood·Corey CutlerEdwin Alyea

❮ Previous
Next ❯

Citations

Jul 27, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Anna Vossenkämper, Jo Spencer
Jun 27, 2012·Bone Marrow Transplantation·B C Beaudette-ZlatanovaP J Stiff
Nov 7, 2012·The Journal of Experimental Medicine·Andrew L SnowMichael J Lenardo
Oct 24, 2012·The Journal of Experimental Medicine·Marc SeifertRalf Küppers
Jul 28, 2010·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Eline T Luning PrakKathleen E Sullivan
Aug 31, 2013·Annual Review of Pathology·Suping Zhang, Thomas J Kipps
Mar 15, 2014·Journal of Clinical Immunology·Mikael SundinAnn-Charlotte Wikström
Sep 29, 2015·Arthritis & Rheumatology·Athanasios MavropoulosLazaros I Sakkas
Sep 6, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Coco de KoningStefan Nierkens
Oct 23, 2009·American Journal of Clinical Pathology·Franklin S FudaWeina Chen
Aug 15, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Angela MensenIl-Kang Na
May 11, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Alessandra SottiniLuisa Imberti
Jun 20, 2008·The Journal of Investigative Dermatology·Hugo MouquetPascal Joly
Oct 28, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ping LiuAndrew M Scharenberg
Nov 28, 2015·Tuberculosis·Willem J du PlessisAndré G Loxton
Jun 5, 2013·Clinical and Experimental Immunology·S AgrawalW A Sewell
Sep 21, 2010·Cytometry. Part B, Clinical Cytometry·M Perez-AndresUNKNOWN Primary Health Care Group of Salamanca for the Study of MBL
Jan 11, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J SmetL Schandené
Feb 11, 2014·The Journal of Allergy and Clinical Immunology·Immacolata BrigidaAlessandro Aiuti
May 20, 2016·Clinical & Translational Immunology·Anna StrömbeckAnna Rudin
Oct 8, 2016·European Journal of Haematology·Geothy ChakupurakalMichael von Bergwelt-Baildon
Apr 20, 2017·Transplantation·Baoshan GaoEmmanuel Zorn
Feb 16, 2019·American Journal of Reproductive Immunology : AJRI·Yaozhu LengNardhy Gomez-Lopez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.