Transitional cell carcinomas of the ovary and bladder are immunophenotypically different

Histopathology
N G Ordóñez

Abstract

Transitional cell carcinoma (TCC) of the ovary is a subtype of ovarian cancer whose main characteristic is its histological resemblance to TCC of the bladder. Thrombomodulin (TM), a surface glycoprotein commonly expressed in normal and neoplastic urothelium, has been proven to be a good marker for TCC of the bladder. To better define the phenotype of TCC of the ovary, we investigated TM, cytokeratin 20 and carcinoembryonic antigen (CEA) expression in 15 TCCs of the ovary and compared their phenotype with that of 20 TCCs of the bladder, and 20 serous and 10 endometrioid carcinomas of the ovary. Immunostaining was performed on formalin-fixed, paraffin-embedded tissue sections using the avidin-biotin-peroxidase complex method. All 20 TCCs of the bladder stained for TM and cytokeratin 20, and 13 stained for CEA. None of the TCCs of the ovary reacted for TM or cytokeratin 20, and only two expressed CEA. All of the serous and endometrioid carcinomas were negative for TM and cytokeratin 20. CEA positivity was observed in two of the serous carcinomas, but in none of the endometrioid carcinomas. The immunophenotype of TCC of the ovary is similar to that of other surface carcinomas of the ovary, but differs from that of TCC of the bladde...Continue Reading

References

Nov 1, 1990·American Journal of Clinical Pathology·K T Chen
Apr 1, 1990·American Journal of Clinical Pathology·E G SilvaD M Gershenson
Jun 1, 1990·Pathology, Research and Practice·F FetissofJ Lansac
Dec 1, 1985·The Journal of Clinical Investigation·H Ishii, P W Majerus
Jan 1, 1987·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R M Austin, H J Norris
Mar 15, 1973·American Journal of Obstetrics and Gynecology·Q Federman, C Toker
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Aug 1, 1995·Human Pathology·C C WautersF C Ramaekers
Apr 1, 1995·The Journal of Pathology·D E JacksonJ A Hayman
May 1, 1994·Histopathology·P CrossJ Coyne
Apr 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·L M RothT M Ulbright
Jul 1, 1995·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R W ThomasonH Dave
Feb 1, 1996·Gynecologic Oncology·G W SpiegelP L Gelven
Jul 1, 1996·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R A SoslowT A Longacre
Aug 1, 1996·Histopathology·M A AppletonB Jasani
Aug 1, 1997·The American Journal of Surgical Pathology·C KoenigF A Tavassoli
Aug 12, 1998·Gynecologic Oncology·E G Silva, D M Gershenson
Sep 5, 1998·American Journal of Clinical Pathology·N G Ordóñez

❮ Previous
Next ❯

Citations

Jun 1, 2010·Pathology Oncology Research : POR·Tito Silvio PatrelliGiovanni Battista Nardelli
Oct 20, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jaime Prat
Sep 19, 2002·Veterinary Ophthalmology·Christina McCowanMichael Lynch
Oct 25, 2003·The American Journal of Surgical Pathology·Nelson G Ordóñez
Jul 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R VangM T Deavers
Dec 12, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jeffrey D SeidmanBrigitte M Ronnett
Sep 29, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Rola H AliC Blake Gilks
Jan 22, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasuhiko IshiiTaiji Tsukamoto
May 10, 2011·Journal of the Chinese Medical Association : JCMA·Chung-Cheng YuYang-Tse Shih
Mar 1, 2011·Surgical Pathology Clinics·Guangming Han, Robert A Soslow
Jun 26, 2009·Human Pathology·C Blake Gilks, Jaime Prat
Feb 24, 2009·Annales de pathologie·Samia Hannachi SassiKhaled Ben Romdhane
Mar 26, 2005·Gynecologic Oncology·Friedrich KommossUNKNOWN Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom
Sep 10, 2003·Hematology/oncology Clinics of North America·Jeffrey D Seidman, Robert J Kurman
Mar 4, 2006·Seminars in Diagnostic Pathology·W Glenn McCluggage, Robert H Young
Nov 9, 2010·Taiwanese Journal of Obstetrics & Gynecology·Habiba KadiriNajat Mahassini
Feb 23, 2011·Food Science and Technology International = Ciencia Y Tecnología De Los Alimentos Internacional·A OlivaresC J López-Bote
Aug 14, 2013·Advances in Anatomic Pathology·Nelson G Ordóñez
Sep 9, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Z GaoO Falkowski
Apr 17, 2004·The American Journal of Surgical Pathology·John H Eichhorn, Robert H Young

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.