PMID: 8944037Dec 1, 1996Paper

Transitional cell carcinomas of the urinary bladder that may be underdiagnosed. A report of four invasive cases exemplifying the homology between neoplastic and non-neoplastic transitional cell lesions

The American Journal of Surgical Pathology
R H Young, Esther Oliva

Abstract

Four unusual invasive transitional carcinomas of the urinary bladder arose in patients aged 70 to 85 years. One or more specimens from each case were misinterpreted as benign. The features that led to diagnostic confusion included nests and trabeculae composed of cells with relatively bland cytologic features and small tubules, medium-sized glands, or cysts that suggested nephrogenic adenoma, cystitis glandularis, or cystitis cystica. In three cases, elongated slit-like lumens or clefts that frequently branched were also present, and several tumors had nests with pointed projections from which neoplastic cells invaded into the adjacent stroma in an often inconspicuous manner. In addition to their unusual patterns and frequent deceptive cytologic features, the tumors were noteworthy because they often had cells with abundant eosinophilic cytoplasm. A variety of architectural features, specifically a disorderly distribution of the epithelial elements, their frequent packed arrangement, and their variation in size and shape, all spoke for a neoplastic interpretation in the current cases. Additionally, in most of these cases, small clusters of cells or individual cells of more conventional invasive carcinoma facilitated the interpr...Continue Reading

References

Oct 1, 1991·Human Pathology·R H Young, J N Eble
Nov 1, 1991·American Journal of Clinical Pathology·R H Young, L R Zukerberg
May 1, 1989·The American Journal of Surgical Pathology·M L Talbert, R H Young
Nov 1, 1995·Journal of Clinical Pathology·M A PittD L Bisset

❮ Previous
Next ❯

Citations

May 13, 1999·Diagnostic Cytopathology·A Lee, Z Baloch
Jun 6, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mahul B Amin
Jun 30, 2004·The American Journal of Surgical Pathology·Theresa Y Chan, Jonathan I Epstein
Mar 4, 2014·Advances in Urology·Anthony Kodzo-Grey Venyo
Nov 22, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mahul B AminMark S Soloway
Sep 24, 1999·The Urologic Clinics of North America·E C Jones
Dec 26, 2009·International Journal of Surgical Pathology·Carlo PatriarcaEnrico Bollito
Sep 23, 2014·The Journal of Urology·Peter A Humphrey
Nov 8, 2007·BJU International·Antonio Lopez-BeltranRodolfo Montironi
Mar 24, 2009·Diagnostic Cytopathology·Hilda Ladenheim, William Frable
Sep 13, 2017·Nature Reviews. Urology·Marco MoschiniShahrokh F Shariat
Mar 15, 2012·International Journal of Surgical Pathology·Borislav A Alexiev, Charles M LeVea
Dec 20, 2018·Histopathology·Antonio Lopez-BeltranLiang Cheng
Dec 17, 2020·Cancers·Claudia Manini, José I López
Aug 9, 2007·Archives of Pathology & Laboratory Medicine·Qihui J ZhaiJae Y Ro
Nov 6, 2007·Archives of Pathology & Laboratory Medicine·Deepti DhallSemra Olgac
Oct 7, 2010·Archives of Pathology & Laboratory Medicine·Lakshmi P Kunju
Jun 29, 2002·Archives of Pathology & Laboratory Medicine·Xavier LeroyBernard Gosselin
Dec 23, 2004·Annals of Diagnostic Pathology·Peter A Humphrey
Sep 24, 1999·The Urologic Clinics of North America·V E Reuter
Dec 1, 2008·Surgical Pathology Clinics·Cristina Magi-GalluzziMing Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.