Transitional status and modifiable risk of frailty in Japanese older adults: A prospective cohort study

Geriatrics & Gerontology International
Takehiko DoiHiroyuki Shimada

Abstract

The purpose of the present study was to identify risk factors for physical frailty and to understand the transitional status of frailty. The participants were 4676 older adults in the National Center for Geriatrics and Gerontology - Study of Geriatric Syndromes. Physical frailty status was classified as robust, pre-frail and frail at baseline and 4-year follow up (mean follow up 47.9 ± 1.8 months). Data for demographic variables, medical conditions, fall, depressive symptoms and cognitive function were also collected. Multiple imputation was used to reduce selection bias and loss of information. Progression occurred from a robust to frail status in 52 participants (2.6%) and from pre-frailty to frailty in 281 participants (12.0%). Mortality increased with frailty status at baseline: robust 46 (2.3%), pre-frail 112 (4.8%) and frail 54 (15.6%). In logistic regression analysis, age (OR 1.10, 95% CI 1.06-1.13), sex (men; OR 0.67, 95% CI 0.46-0.95), body mass index (OR 1.06, 95% CI 1.01-1.12]), fall (OR 1.92, 95% CI 1.31-2.81), Geriatric Depression Scale (OR 1.15, 95% CI 1.08-1.22), Mini-Mental State Examination (OR 0.87, 95% CI 0.82-0.93) and education (OR 0.91, 95% CI 0.85-0.98), were related with new incident frailty. Among parti...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Mar 1, 2006·Archives of Internal Medicine·Thomas M GillLing Han
Feb 27, 2008·Archives of Internal Medicine·Kristine E EnsrudSteven R Cummings
Jan 18, 2012·Nature Reviews. Rheumatology·Joop P van den BerghPiet P Geusens
Feb 10, 2012·Journal of the American Geriatrics Society·Sara E EspinozaHelen Hazuda
Aug 14, 2012·Journal of the American Geriatrics Society·Rose M CollardRichard C Oude Voshaar
Dec 19, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Vincenzo SolfrizziUNKNOWN Italian Longitudinal Study on Aging Working Group
May 15, 2013·Journal of the American Medical Directors Association·Hiroyuki ShimadaTakao Suzuki
Jul 3, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jason L SandersAnne B Newman
Jan 28, 2014·Journal of the American Medical Directors Association·Liang-Kung ChenHidenori Arai
Feb 19, 2014·Journal of the American Medical Directors Association·Jenny S W LeeJean Woo
Feb 7, 2015·Geriatrics & Gerontology International·Hidenori AraiShinichi Ohshima
May 9, 2015·Geriatrics & Gerontology International·Hiroyuki ShimadaTakao Suzuki
Sep 29, 2015·Journal of the American Medical Directors Association·Kota TsutsumimotoTakao Suzuki
Oct 21, 2015·Journal of the American Medical Directors Association·Hyuma MakizakoTakao Suzuki
Aug 9, 2016·The Journal of Nutrition, Health & Aging·H ShimadaT Suzuki
Nov 20, 2016·Journal of the American Geriatrics Society·Caterina TrevisanGiuseppe Sergi
Feb 1, 2017·Journal of Epidemiology·Gotaro KojimaKate Walters
Jan 5, 2018·The Journal of Nutrition, Health & Aging·T DoiH Shimada

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Citations

Sep 3, 2019·Health & Social Care in the Community·Hiroyuki UmegakiMasafumi Kuzuya
Jul 17, 2020·Internal Medicine·Daisuke AsaokaAkihito Nagahara
Dec 31, 2019·The Journal of Nutrition, Health & Aging·C Y CheongT P Ng
Oct 23, 2019·International Journal of Environmental Research and Public Health·Takumi AbeShoji Shinkai
Oct 9, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Masashi KanaiShinichi Shimada
Jan 6, 2021·Alzheimer's Research & Therapy·Linzy BohnRoger A Dixon

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