Transitions between repetitive tapping and upper limb freezing show impaired movement-related beta band modulation.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Marlieke ScholtenDaniel Weiss

Abstract

Freezing phenomena in idiopathic Parkinson's disease (PD) constitute an important unaddressed therapeutic need. Changes in cortical neurophysiological signatures may precede a single freezing episode and indicate the evolution of abnormal motor network processes. Here, we hypothesize that the movement-related power modulation in the beta-band observed during regular finger tapping, deteriorates in the transition period before upper limb freezing (ULF). We analyzed a 36-channel EEG of 13 patients with PD during self-paced repetitive tapping of the right index finger. In offline analysis, we compared the transition period immediately before ULF ('transition') with regular tapping regarding movement-related power modulation and interregional phase synchronization. From time-frequency analyses, we observed that the tap cycle related beta-band power modulation over the left sensorimotor area was diminished in the transition period before ULF. Furthermore, increased beta-band power was observed in the transition period compared to regular tapping centered over the left centro-parietal and right frontal areas. Phase synchronization between the left fronto-parietal areas and the left sensorimotor area was elevated during transition com...Continue Reading

Citations

Aug 11, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Karim Johari, Roozbeh Behroozmand

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