Transjugular intrahepatic portosystemic shunt: impact on systemic hemodynamics and renal and cardiac function in patients with cirrhosis

American Journal of Physiology. Gastrointestinal and Liver Physiology
Troels M BuskSøren Møller

Abstract

Transjugular intrahepatic portosystemic shunt (TIPS) alleviates portal hypertension and possibly increases central blood volume (CBV). Moreover, renal function often improves; however, its effects on cardiac function are unclear. The aims of our study were to examine the effects of TIPS on hemodynamics and renal and cardiac function in patients with cirrhosis. In 25 cirrhotic patients, we analyzed systemic, cardiac, and splanchnic hemodynamics by catheterization of the liver veins and right heart chambers before and 1 wk after TIPS. Additionally, we measured renal and cardiac markers and performed advanced echocardiography before, 1 wk after, and 4 mo after TIPS. CBV increased significantly after TIPS (+4.6%, P < 0.05). Cardiac output (CO) increased (+15.3%, P < 0.005) due to an increase in stroke volume (SV) (+11.1%, P < 0.005), whereas heart rate (HR) was initially unchanged. Cardiopulmonary pressures increased after TIPS, whereas copeptin, a marker of vasopressin, decreased (-18%, P < 0.005) and proatrial natriuretic peptide increased (+52%, P < 0.0005) 1 wk after TIPS and returned to baseline 4 mo after TIPS. Plasma neutrophil gelatinase-associated lipocalin, renin, aldosterone, and serum creatinine decreased after TIPS (-3...Continue Reading

References

Dec 1, 1989·Gastroenterology·J H HenriksenH Ring-Larsen
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R W SchrierJ Rodés
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M GuevaraJ Rodés
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L GerbesM Reiser
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E LottererW E Fleig
Apr 9, 2001·American Journal of Physiology. Renal Physiology·R S PedersenE B Pedersen
May 16, 2001·American Journal of Physiology. Renal Physiology·H HagerS Nielsen
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Simon C Malpas
Jan 26, 2002·The American Journal of Gastroenterology·Manuela MerliOliviero Riggio
Feb 28, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Søren MøllerFlemming Bendtsen
Mar 4, 2003·Gastroenterology·Arun J SanyalUNKNOWN North American Study for the Treatment of Refractory Ascites Group
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luis Ruiz-del-ArbolVicente Arroyo
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francesco SalernoLarry Burdick
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florence WongKenneth Sniderman
Jun 25, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luis Ruiz-del-ArbolVicente Arroyo
Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christina Esteva-FontPere Ginès
Jan 16, 2008·Journal of Hepatology·Andrea ZambruniMauro Bernardi
Jun 18, 2009·The American Journal of Gastroenterology·Rania Nancy RabieFlorence Wong
Nov 11, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas D BoyerUNKNOWN American Association for the Study of Liver Diseases
Mar 20, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas Guldager LauridsenErling B Pedersen
Nov 18, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Aleksander KragFlemming Bendtsen
Jan 21, 2012·American Journal of Physiology. Renal Physiology·Carolina Cannillo GraffeErling Bjerregaard Pedersen
Sep 29, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Søren MøllerJan L Madsen
Jun 15, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Christian MortensenFlemming Bendtsen
Feb 1, 2015·Scandinavian Journal of Gastroenterology·Marianne GeilswijkHenning Grønbæk
Mar 10, 2015·JACC. Cardiovascular Imaging·Magnus Thorsten JensenJan Skov Jensen
Apr 2, 2015·The New England Journal of Medicine·Mark A KnepperSoren Nielsen
Oct 3, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Daniela FilìJaime Bosch

❮ Previous
Next ❯

Citations

Feb 26, 2019·Expert Review of Gastroenterology & Hepatology·Søren MøllerFlemming Bendtsen
Jun 20, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Signe WieseSøren Møller
May 22, 2018·F1000Research·Tilman SauerbruchJonel Trebicka
Nov 15, 2019·Nature Reviews. Nephrology·Juan Carlos Q VelezLuis A Juncos
Jan 6, 2021·Internal and Emergency Medicine·Maria Pilar BallesterMiguel Mínguez
Jan 27, 2021·Radiology·David C MadoffCharles E Ray
Jul 19, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Justin R BoikeUNKNOWN Advancing Liver Therapeutic Approaches (ALTA) Consortium

❮ Previous
Next ❯

Methods Mentioned

BETA
affinity purification
RAP

Software Mentioned

QLAB

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.