Transjugular intrahepatic portosystemic shunt versus endoscopic sclerotherapy for the prevention of variceal bleeding in cirrhosis: a randomized multicenter trial. Gruppo Italiano Studio TIPS (G.I.S.T.)

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M MerliP Rossi

Abstract

Transjugular intrahepatic portosystemic shunt (TIPS), a new technique for the treatment of portal hypertension, has been successful in preliminary studies to treat acute variceal hemorrhage and to prevent variceal rebleeding. The purpose of this multicenter, randomized controlled trial is to compare the efficacy of TIPS with that of endoscopic sclerotherapy in the prevention of variceal rebleeding in cirrhosis. Eighty-one cirrhotic patients, with endoscopically proven variceal bleeding, were randomized to either TIPS (38 patients) or endoscopic sclerotherapy (43 patients). Randomization was stratified according to the following: if bleeding occurred < 1 week (stratum I); if bleeding occurred 1 to 6 weeks (stratum II); and if bleeding occurred 6 weeks to 6 months (stratum III) before enrollment. Follow-up included clinical, biochemical, Doppler Ultrasound, and endoscopic examinations every 6 months. During a mean follow-up of 17.7 months, 51% of the patients treated with sclerotherapy and 24% of those treated with TIPS rebled (P = .011). Mortality was 19% in sclerotherapy patients and 24% in TIPS patients (P = .50). Hepatic encephalopathy (HE) developed in 26% and 55%, respectively (P = .006). A separate analysis of the three st...Continue Reading

References

Oct 1, 1992·Gastroenterology·W M Lee
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G D'AmicoJ Bosch
May 4, 1995·The New England Journal of Medicine·A OchsH E Blum
Jul 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J SanyalA K Cheatham
Jan 20, 1994·The New England Journal of Medicine·M RössleK Hauenstein

❮ Previous
Next ❯

Citations

Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G V PapatheodoridisA K Burroughs
Jul 23, 1999·Cardiovascular and Interventional Radiology·D Y SzeM D Dake
Sep 12, 2000·Current Gastroenterology Reports·A J Sanyal
Jan 18, 2003·Current Gastroenterology Reports·Timothy M McCashland
Jun 11, 1999·Disease-a-month : DM·S Kaur, S Cotler
May 23, 2003·Gastroenterology·Thomas D Boyer
Mar 12, 1999·The Surgical Clinics of North America·H E VargasK Abu-Elmagd
May 1, 2001·Alimentary Pharmacology & Therapeutics·A Helmy, P C Hayes
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bernhard AngermayrUNKNOWN Vienna TIPS Study Group
Jan 15, 2000·Journal of Clinical Gastroenterology·J P OngZ M Younossi
Mar 15, 2000·Gut·R JalanP C Hayes
Sep 22, 2012·AJR. American Journal of Roentgenology·Nicholas FidelmanRobert K Kerlan
Nov 20, 2002·AJR. American Journal of Roentgenology·Zhen W ZhuangMichael A Bettmann
Jan 18, 2013·World Journal of Gastroenterology : WJG·Hui XueZhi-Lun Wang
Aug 22, 2013·World Journal of Gastroenterology : WJG·Erwin Biecker
Sep 24, 2009·The Indian Journal of Radiology & Imaging·Sundeep J Punamiya
Aug 14, 2012·International Journal of Hepatology·Gilles Pomier-LayrarguesPierre Perreault
Dec 2, 2014·Clinics in Liver Disease·Kavish R PatidarArun J Sanyal
Oct 12, 2013·World Journal of Gastroenterology : WJG·Romaric LoffroyJean-Pierre Cercueil
May 8, 2001·European Journal of Gastroenterology & Hepatology·M Rössle
May 8, 2001·European Journal of Gastroenterology & Hepatology·J P Ong, K D Mullen
Apr 21, 2004·European Journal of Gastroenterology & Hepatology·Dhiraj TripathiPeter C Hayes
Oct 13, 2006·European Journal of Gastroenterology & Hepatology·James W Ferguson, Peter C Hayes
Mar 12, 2003·Current Treatment Options in Gastroenterology·Joseph J. Y. Sung
Oct 14, 2011·International Journal of Hepatology·Sundeep J Punamiya, Deepak N Amarapurkar
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M W RussoR S Brown
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K BarangeJ P Vinel
Mar 19, 2004·Journal of Vascular and Interventional Radiology : JVIR·Richard R Saxon
Mar 19, 2004·Journal of Vascular and Interventional Radiology : JVIR·Klaus A HauseggerAndrea Berghold
Feb 11, 2012·Clinics in Liver Disease·Oliviero RiggioManuela Merli
Mar 2, 2016·The American Journal of Gastroenterology·Silvia NardelliOliviero Riggio
Dec 29, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Oliviero RiggioStefania Angeloni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.