Transkull focal lesions in cat brain produced by ultrasound

Journal of Neurosurgery
F J FRYJ T Patrick

Abstract

Focused ultrasound has been used for focal modifications of brain tissue and in preliminary studies of the application of ultrasonic techniques for tissue modification in human stereotaxic neurosurgery; however, the technique has been seriously compromised by the necessity of removal of intervening skull. Such removal was necessary to avoid distortion and extremely large attenuation of the ultrasonic beam which resulted from passage through bone. Recent studies have shown that under proper conditions focal beams of ultrasound can be transmitted with tolerable and attenuation through skull, suggesting the possibility of transkull lesion production in brain. This report describes the acoustical parameters and histological features of focal brain lesions produced in 10 craniectomized cats with intense focal ultrasonic beams which first had passed through a formalin-fixed human skull overlay. The histological appearance of these lesions produced to date is similar to that produced previously without intervening skull.

References

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Citations

Jun 25, 2002·Ultrasound in Medicine & Biology·G T Clement, Kullervo Hynynen
Dec 10, 2002·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·Michael Daffertshofer, Marc Fatar
Aug 10, 2013·Medical Physics·David SchlesingerJames Larner
Aug 22, 2009·IEEE Transactions on Bio-medical Engineering·Sai Chun Tang, Gregory T Clement
May 7, 2002·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Greg T Clement, Kullervo Hynynen
Dec 17, 2015·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Alyona HaritonovaEmad S Ebbini
Jun 8, 2013·Ultrasound in Medicine & Biology·Hiroshi Furuhata, Osamu Saito
Jun 21, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K Hynynen, G Clement

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