Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.

Cellular Signalling
Amber A ParnellLisa C Lyons

Abstract

The endogenous circadian clock functions to maintain optimal physiological health through the tissue specific coordination of gene expression and synchronization between tissues of metabolic processes throughout the 24 hour day. Individuals face numerous challenges to circadian function on a daily basis resulting in significant incidences of circadian disorders in the United States and worldwide. Dysfunction of the circadian clock has been implicated in numerous diseases including cancer, diabetes, obesity, cardiovascular and hepatic abnormalities, mood disorders and neurodegenerative diseases. The circadian clock regulates molecular, metabolic and physiological processes through rhythmic gene expression via transcriptional and post-transcriptional processes. Mounting evidence indicates that post-transcriptional regulation by the circadian clock plays a crucial role in maintaining tissue specific biological rhythms. Circadian regulation affecting RNA stability and localization through RNA processing, mRNA degradation, and RNA availability for translation can result in rhythmic protein synthesis, even when the mRNA transcripts themselves do not exhibit rhythms in abundance. The circadian clock also targets the initiation and elo...Continue Reading

References

Dec 1, 1978·The Journal of Physiology·J N MillsJ M Waterhouse
Oct 1, 1975·Clinical Pharmacology and Therapeutics·C A Shively, E S Vesell
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Paul E HardinMichael Rosbash
Jan 1, 1991·Chronobiology International·H NagayamaT Tashiro
Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D P Lotshaw, J W Jacklet
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D MorseJ W Hastings
Sep 1, 1987·Gastroenterology·R H GooN P Alazraki
Jun 7, 1968·Science·S Gaston, M Menaker
Aug 1, 1984·Clinical Pharmacology and Therapeutics·S NakanoN Ogawa
Mar 1, 1980·British Journal of Clinical Pharmacology·C A NaranjoJ G Abel
Apr 1, 1983·Clinical Pharmacology and Therapeutics·S Nakano, L E Hollister
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Takao KondoCarl Hirschie Johnson
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·Carla B Green, Joseph C Besharse
Jan 10, 1997·Science·Takao KondoSusan S Golden
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·J B HogeneschChristopher A Bradfield
Jun 11, 1998·Science·N GekakisCharles J Weitz
Jul 17, 1998·Headache·A W Fox, R L Davis
Mar 13, 1999·Progress in Brain Research·D MurphyC A Robinson
Apr 10, 1999·Nature Neuroscience·Karl ObrietanDaniel R Storm
Jul 27, 1999·Science·M Fernanda CerianiS A Kay
Oct 26, 1999·Science·Nicholas R J GlossopPaul E Hardin
Mar 9, 2000·Drug Metabolism and Drug Interactions·A T BapujiS S Apte
May 12, 2000·Science·L P ShearmanS M Reppert
Feb 13, 2001·Science·K A StokkanM Menaker
Jun 8, 2001·BMC Developmental Biology·Y WangJoseph C Besharse
Jul 21, 2001·Seminars in Cell & Developmental Biology·T Mori, Carl Hirschie Johnson
Feb 9, 2002·Science·David M BersonMotoharu Takao
Apr 23, 2002·Nature·Kai-Florian StorchCharles J Weitz
May 23, 2002·Cell·Satchidananda PandaJohn B Hogenesch
Jun 4, 2002·The Journal of Biological Chemistry·Greg Q ButcherKarl Obrietan
Oct 25, 2002·Nature·Sato HonmaKen-Ichi Honma
Jul 12, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher S ColwellJames A Waschek
Oct 1, 2003·Journal of Clinical Pharmacology·Suryanarayana SistaKenneth S Albert
Nov 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Raymond I FernandezArnold Eskin
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel Granados-FuentesErik D Herzog
Mar 11, 2004·The European Journal of Neuroscience·Daniel Granados-FuentesErik D Herzog
Apr 23, 2004·Trends in Biochemical Sciences·Richard S Jope, Gail V W Johnson
Jun 10, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Atsuko TakanoTakashi Ebisawa
Mar 16, 2005·Molecular and Cellular Biology·E J EideDavid Virshup
Apr 21, 2005·RNA·Maria Alexandra AndreiReinhard Lührmann
Apr 23, 2005·Science·Fred W TurekJoseph Bass
Apr 27, 2005·Journal of Biological Rhythms·Michelle BrewerAna Anzulovich
Jun 14, 2005·Nature Reviews. Genetics·Deborah Bell-PedersenMark J Zoran
Jun 24, 2005·The Journal of Biological Chemistry·Chisato IitakaNorio Ishida
Jul 16, 2005·Annals of Medicine·Hader A MansourVishwajit L Nimgaonkar
Jul 28, 2005·Current Opinion in Nephrology and Hypertension·Ramón C HermidaCarlos Calvo
Aug 19, 2005·Genes & Development·Axel C R DiernfellnerMichael Brunner
Aug 20, 2005·Science·Luca CardonePaolo Sassone-Corsi
Aug 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lisa C LyonsArnold Eskin
Apr 6, 2006·Journal of Biosciences·Dipankar NandiDilip Chandu
May 9, 2006·Cell·Masao DoiPaolo Sassone-Corsi
May 12, 2006·Chronobiology International·Marc WittmannTill Roenneberg
Aug 25, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisa C LyonsArnold Eskin
Nov 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel Granados-FuentesErik D Herzog
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Carla B GreenJoseph C Besharse
Jun 1, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Akhilesh B ReddyMichael H Hastings
Dec 14, 2007·Nature·Jun HirayamaPaolo Sassone-Corsi
Jan 1, 2008·Journal of Bacteriology·Yoriko MurayamaTakao Kondo
Feb 6, 2008·Expert Opinion on Drug Metabolism & Toxicology·Massimo Baraldo
Feb 21, 2008·BMC Genomics·Maocheng YangIsaac Edery
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·L SaezM W Young
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·Elizabeth S MaywoodMichael H Hastings
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·Sandra M SiepkaJoseph S Takahashi
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·David VirshupE Vielhaber Harnish
Jul 26, 2008·Molecular Biology of the Cell·Adva AizerYaron Shav-Tal
Sep 26, 2008·Journal of Medicinal Chemistry·Konstantina VougogiannopoulouLaurent Meijer
Oct 11, 2008·PLoS Computational Biology·Jun YanChunxuan Shao
Dec 9, 2008·Journal of Biological Rhythms·Lisa C LyonsArnold Eskin
Dec 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tsuyoshi HirotaSteve A Kay
Jan 23, 2009·Nature Neuroscience·Kristin L Eckel-MahanDaniel R Storm
Jan 27, 2009·Journal of Neurochemistry·Michael L KoGladys Y-P Ko
Mar 17, 2009·Science·Yasukazu NakahataPaolo Sassone-Corsi
Mar 21, 2009·Science·Kathryn Moynihan RamseyJoseph Bass
Apr 8, 2009·Trends in Endocrinology and Metabolism : TEM·M Mahmood Hussain, Xiaoyue Pan
Jun 3, 2009·Genes & Development·David GatfieldUeli Schibler
Jul 21, 2009·Acta Histochemica Et Cytochemica·Kazuhiro YagitaYasuo Uchiyama
Aug 22, 2009·Genes & Development·Sebastian KadenerMichael Rosbash
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alex Y -L SoBrian J Feldman
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yasushi IsojimaHiroki R Ueda
Dec 1, 2009·Cell Cycle·Mary L SpenglerMarina P Antoch
Feb 11, 2010·Biochemical Pharmacology·Young-Sil LeeJe-Tae Woo
Mar 30, 2010·Journal of Biological Rhythms·Karine ScheuermaierJeanne F Duffy
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ruifeng CaoKarl Obrietan
Jun 15, 2010·Advanced Drug Delivery Reviews·Siddharth SukumaranWilliam J Jusko
Aug 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Qing-Jun MengAndrew S Loudon
Aug 26, 2010·ACS Chemical Biology·Yongjun WangThomas P Burris
Sep 24, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hyuk Wan KoIsaac Edery
Dec 7, 2010·The British Journal of Dermatology·B L Diffey
Jan 29, 2011·Nature·John S O'Neill, Akhilesh B Reddy
Apr 12, 2011·PloS One·Christine Crumbley, Thomas P Burris
May 4, 2011·FEBS Letters·Martha Merrow, Michael Brunner
Jul 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Trongha X PhanDaniel R Storm
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth S MaywoodMichael H Hastings
Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason R GerstnerCharles F Landry
Apr 5, 2012·Genome Research·Michael E HughesMichael N Nitabach
Apr 10, 2012·PloS One·M Ann KellySAT2D Consortium
Jun 23, 2012·Genome Biology·Nicholas J McGlincyJernej Ule
Jul 6, 2012·Cold Spring Harbor Perspectives in Biology·Carolyn J Decker, Roy Parker
Jul 17, 2012·Science·Tsuyoshi HirotaSteve A Kay
Aug 11, 2012·PLoS Biology·Brigitte GrimaFrançois Rouyer
Aug 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mary L SpenglerMarina P Antoch
Dec 20, 2012·Genes & Development·Shihoko KojimaCarla B Green
Jan 10, 2013·PLoS Biology·Céline JouffeFrederic Gachon
Jan 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Selma MasriPaolo Sassone-Corsi
Mar 8, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maximilian MichelLisa C Lyons
Apr 19, 2013·American Journal of Physiology. Cell Physiology·T ShavlakadzeM D Grounds
Aug 6, 2013·Current Biology : CB·Kenneth P WrightEvan D Chinoy
Oct 29, 2013·Annual Review of Pharmacology and Toxicology·Robert DallmannFrederic Gachon
Dec 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daniel MauvoisinFelix Naef
Jan 8, 2014·Nature Communications·Yubin WangMichel Baudry
Jan 9, 2014·Chronobiology International·Véronique Pasquale RocheFrancis Lévi
Feb 1, 2014·Aging·Rohini V KhapreRoman V Kondratov
Feb 22, 2014·International Journal of Environmental Research and Public Health·Carlyn J MatzOrly Brion
Feb 26, 2014·JAMA Neurology·Aleksandar VidenovicPhyllis C Zee
Mar 1, 2014·Nature Reviews. Drug Discovery·Douglas J Kojetin, Thomas P Burris
Mar 8, 2014·Journal of Experimental Botany·Zhibo CuiXiaoxue Wang
Jun 5, 2014·Current Drug Delivery·Swati C Jagdale, Chandrakala R Pawar
Jul 27, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jana HusseGregor Eichele
Aug 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Marion CornuMichael N Hall
Dec 1, 2012·Therapeutic Advances in Drug Safety·Basil N OkeahialamJayne Na Ajuluchukwu
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ray ZhangJohn B Hogenesch
Nov 12, 2014·Nature Reviews. Neurology·Aleksandar VidenovicSebastiaan Overeem
Dec 24, 2014·Nature Communications·Subhashis BanerjeeThomas P Burris
Apr 14, 2015·Current Biology : CB·Helen C CaustonJohn S O'Neill
Apr 29, 2015·Nature Neuroscience·Ruifeng CaoNahum Sonenberg
May 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Anne M CurtisLuke A J O'Neill
Sep 1, 2015·Nature Structural & Molecular Biology·Alfred G TamayoCharles J Weitz
Sep 24, 2015·The Plant Cell·Anamika MissraAlbrecht G von Arnim
Nov 11, 2015·Proceedings of the National Academy of Sciences of the United States of America·Florian AtgerFrederic Gachon
Dec 19, 2015·BioMed Research International·Shujing Li, Luoying Zhang
Feb 13, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong ZhangPatrick Emery
Feb 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Mathew D EdwardsMichael H Hastings
Feb 24, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mohd Abdul HadiA Srinivasa Rao
Feb 28, 2016·Nucleic Acids Research·Nicole LudwigAndreas Keller
Apr 6, 2016·The Journal of Cell Biology·Konstantin Licht, Michael F Jantsch
Jun 5, 2016·Journal of Molecular Biology·Aditya Radhakrishnan, Rachel Green
Jul 5, 2016·Canadian Journal of Physiology and Pharmacology·Yanhong ChenJiangang Zou
Jul 8, 2016·Science Advances·Fabio FalchiRiccardo Furgoni
Aug 2, 2016·Cell Metabolism·Thales PapagiannakopoulosTyler Jacks
Aug 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Stephen Z CasterDeborah Bell-Pedersen
Sep 28, 2016·Nature Neuroscience·Sarah NainarTimothy W Bredy
Nov 8, 2016·Cell Metabolism·Jingkui WangFrederic Gachon
Nov 29, 2016·Nature Genetics·Hideki TerajimaYoshitaka Fukada
Dec 7, 2016·Nature Structural & Molecular Biology·Arisa HiranoLouis J Ptáček
Dec 19, 2016·Nature Reviews. Genetics·Joseph S Takahashi
Mar 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yakun WuJianping Gong
Apr 30, 2017·Journal of Biological Rhythms·Amelia K LucianoWilliam C Sessa
Jun 18, 2017·Cell·Ian A RoundtreeChuan He
Jun 24, 2017·Metabolism: Clinical and Experimental·Estefania Espitia-BautistaCarolina Escobar
Jul 11, 2017·Molecular Cell·Marco PreußnerFlorian Heyd
Aug 10, 2017·Cancer Research·Frank CichockiJeffrey S Miller
Aug 17, 2017·Cell Reports·Daniel MauvoisinFrederic Gachon
Aug 29, 2017·Journal of Pharmacological Sciences·Yuki FujiwaraAkio Fujimura
Sep 26, 2017·Cephalalgia : an International Journal of Headache·Wpj van OosterhoutG M Terwindt
Oct 3, 2017·Annual Review of Pharmacology and Toxicology·Zheng ChenJoseph S Takahashi
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Seung-Hee YooJoseph S Takahashi
Oct 7, 2017·Molecular Cell·Ran LinKun-Liang Guan
Oct 19, 2017·Cold Spring Harbor Perspectives in Biology·Koji L Ode, Hiroki R Ueda
Nov 28, 2017·Journal of Biological Rhythms·Louise L HansenGerben van Ooijen
Nov 28, 2017·Journal of Biological Rhythms·Louise L HansenGerben van Ooijen
Nov 29, 2017·Science Advances·Christopher C M KybaLuis Guanter
Dec 8, 2017·Nature Communications·Erin A HensleeFatima H Labeed
Jan 15, 2018·Molecular Metabolism·Sarbani GhoshalAndrew A Butler
Feb 10, 2018·Wiley Interdisciplinary Reviews. RNA·Manon TorresAnne-Marie François-Bellan
Mar 29, 2018·The Journal of Biological Chemistry·Amelia K LucianoWilliam C Sessa
Apr 4, 2018·Molecular and Cellular Biology·Philippe P Roux, Ivan Topisirovic
May 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jean-Michel FustinHitoshi Okamura
Jun 19, 2018·Indian Journal of Endocrinology and Metabolism·Vivek G PatwardhanAnuradha V Khadilkar
Jun 27, 2018·Physiology & Behavior·Kaitlin H Snider, Karl Obrietan
Aug 2, 2018·Proceedings of the National Academy of Sciences of the United States of America·Hyunmin KimHong Gil Nam
Oct 6, 2018·Experimental & Molecular Medicine·Teng-Jiao MaYong-Xin Ma
Oct 6, 2018·Scientific Reports·Hideki TerajimaYoshitaka Fukada
Feb 3, 2019·Biochemical Society Transactions·Giovanna Grimaldi, Daniela Corda
Mar 6, 2019·Cell Death & Disease·Ruiqi WangJin Xu
Mar 23, 2019·Journal of Biological Rhythms·Andrew D BealeFatima H Labeed
Apr 30, 2019·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Daniel Mauvoisin
Jun 1, 2019·Cell·Kevin B KoronowskiPaolo Sassone-Corsi
Jun 11, 2019·Annual Review of Nutrition·Amandine ChaixSatchidananda Panda
Jul 13, 2019·International Journal of Molecular Sciences·Akira Nakajima, Yasushi Ohizumi
Jul 13, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lidija ChakuleskaRumyana Simeonova
Aug 8, 2019·Cell Metabolism·Christopher R CederrothBarbara Canlon
Aug 29, 2019·Cancer Discovery·Zhen DongJeremy N Rich
Sep 12, 2019·Journal of the American Chemical Society·Dušan KolarskiBen L Feringa
Oct 12, 2019·Science·Franziska BrüningMaria S Robles
Oct 19, 2019·Molecular Cell·Ji-Young YounAnne-Claude Gingras
Nov 19, 2019·Frontiers in Cellular Neuroscience·Melisa MalcolmEduardo Garbarino-Pico
Dec 8, 2019·Advances in Experimental Medicine and Biology·Hadjara Sidibé, Christine Vande Velde
Dec 19, 2019·Genome Medicine·Filipa Rijo-Ferreira, Joseph S Takahashi
Dec 20, 2019·Nature Communications·Shunsuke HasegawaSatoshi Kida
Dec 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Isara LaothamatasCarla B Green
Jan 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Gareth B KitchenDavid W Ray
Jan 28, 2020·PLoS Computational Biology·Roger J W HillAnnabelle Ballesta
Feb 15, 2020·Science·Sandipan RayAkhilesh B Reddy
Apr 20, 2020·Journal of Molecular Biology·Axel C R Diernfellner, Michael Brunner
May 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Shanta KarkiDeborah Bell-Pedersen
May 27, 2020·JCI Insight·Chengming FanJianyi Zhang
Jun 2, 2020·Current Genomics·Yoshimi Okamoto-UchidaJun Hirayama
Jun 3, 2020·Cold Spring Harbor Symposia on Quantitative Biology·Giulia Ada Corbet, Roy Parker
Jul 28, 2020·Journal of Neurochemistry·Shashank Srikanta, Nicolas Cermakian
Nov 10, 2020·Cell Death & Disease·Chuan YangYufeng Xiao
Dec 17, 2020·Frontiers in Physiology·Andrea Brenna, Urs Albrecht

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