Translating emerging research on the genetics of smoking into clinical practice: ethical and social considerations

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Alexandra E ShieldsP F Sullivan

Abstract

Despite decades of research aimed at improving the effectiveness of smoking treatment, available treatments are only modestly effective, and smoking remains the leading cause of preventable deaths in the United States. Recent research on genetic factors related to smoking behavior eventually may lead to the design of new tobacco dependence treatments and to the individualization of treatment based on genetic factors. Although this research is in its infancy, and data on the analytic and clinical validity of genetic tests to tailor smoking treatment are not yet available, it is not too soon to begin identifying and addressing key ethical issues associated with genetic testing in the context of tobacco dependence treatment. Key concerns include (a) potential harm (e.g., stigmatization, discrimination) to patients related to inappropriate use of genetic information, (b) implications of pleiotropic associations, (c) differential prevalence of risk-conferring genotypes among racial or ethnic subpopulations, (d) preparedness of primary care physicians to incorporate genetic testing into smoking treatment, (e) informed consent, and (f) ensuring an appropriate balance between individually tailored treatment by genotype and broad-based ...Continue Reading

Associated Clinical Trials

Citations

Oct 5, 2007·Current Psychiatry Reports·Robert A SchnollCaryn Lerman
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caryn LermanWade Berrettini
Mar 19, 2008·The Pharmacogenomics Journal·D F HeitjanC Lerman
Jun 28, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alexandra E ShieldsCaryn Lerman
Nov 7, 2006·The American Journal of Bioethics : AJOB·Vardit Ravitsky, Benjamin S Wilfond
Jul 28, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Timothy B BakerStephanie S O'Malley
Aug 12, 2009·Psychiatric Genetics·Marilyn E Coors, Kristen M Raymond
Mar 3, 2011·Addiction Biology·Jessica E SturgessDaniel J Müller
Apr 20, 2005·Journal of General Internal Medicine·Alexandra E ShieldsCaryn Lerman
Mar 21, 2007·Annual Review of Public Health·Ronald M DavisPrakash C Gupta
Apr 29, 2010·Genome Medicine·Helena FurbergPatrick F Sullivan
Jul 15, 2005·Pharmacogenomics·Marcus R MunafòCaryn Lerman
Jan 11, 2014·Personalized Medicine·Alexandra Elizabeth ShieldsAnna Boonin Schachter
May 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Kay WilhelmPeter R Schofield
Dec 6, 2007·American Journal of Preventive Medicine·Caryn E LermanMarcus R Munafò
Jun 20, 2007·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Kenneth P TercyakLeslie R Walker
Nov 22, 2012·Addiction·Jennifer Ware, Marcus R Munafò
Sep 25, 2007·Biochemical Pharmacology·Christina N Lessov-SchlaggarGary E Swan
Apr 7, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Kimberly Kobus, Robin Mermelstein
Jan 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Caryn LermanWade Berrettini
Sep 9, 2005·Health Education & Behavior : the Official Publication of the Society for Public Health Education·Susan K Peterson

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