Translating Genetic Research into Preventive Intervention: The Baseline Target Moderated Mediator Design

Frontiers in Psychology
George HowePeter A Wyman

Abstract

In this paper we present and discuss a novel research approach, the baseline target moderated mediation (BTMM) design, that holds substantial promise for advancing our understanding of how genetic research can inform prevention research. We first discuss how genetically informed research on developmental psychopathology can be used to identify potential intervention targets. We then describe the BTMM design, which employs moderated mediation within a longitudinal study to test whether baseline levels of intervention targets moderate the impact of the intervention on change in that target, and whether change in those targets mediates causal impact of preventive or treatment interventions on distal health outcomes. We next discuss how genetically informed BTMM designs can be applied to both microtrials and full-scale prevention trials. We use simulated data to illustrate a BTMM, and end with a discussion of some of the advantages and limitations of this approach.

References

Dec 1, 1991·American Journal of Community Psychology·I N SandlerJ C Gersten
Sep 27, 2002·Drug and Alcohol Dependence·David P MacKinnonAntonio A Morgan-Lopez
Dec 16, 2004·Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43)·George W HoweRobert D Caplan
Sep 27, 2008·Annual Review of Psychology·John J McArdle
Apr 28, 2010·Prevention Science : the Official Journal of the Society for Prevention Research·George W HoweGene H Brody
Oct 5, 2010·Development and Psychopathology·Darya Bonds McClainRoger E Millsap
Oct 20, 2010·Psychological Methods·Kosuke ImaiDustin Tingley
Nov 23, 2011·Journal of Consulting and Clinical Psychology·Nancy A GonzalesSu Yeong Kim
Jan 9, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Gene H BrodySteven R H Beach
Nov 14, 2013·Journal of Traumatic Stress·Florence GressierAlessandro Serretti
Jan 7, 2014·Prevention Science : the Official Journal of the Society for Prevention Research·Tatiana PerrinoC Hendricks Brown
Apr 16, 2014·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Michaeline R JensenStefany Coxe
May 7, 2014·Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43)·Jessie J WongRoger E Millsap
Nov 25, 2014·Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43)·Ashlea M KlahrS Alexandra Burt

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Citations

Jul 21, 2017·Prevention Science : the Official Journal of the Society for Prevention Research·George W Howe
Apr 22, 2021·Prevention Science : the Official Journal of the Society for Prevention Research·Ahnalee BrincksGuillermo Prado
Aug 2, 2021·Prevention Science : the Official Journal of the Society for Prevention Research·Jingchen ZhangAbigail H Gewirtz
Sep 24, 2021·Journal of Behavioral Medicine·Andrea C JohnsonDarren Mays

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