Translation attenuation regulation of chloramphenicol resistance in bacteria--a review

Gene
P S Lovett

Abstract

The chloramphenicol (Cm)-inducible cat and cmlA genes are regulated by translation attenuation, a regulatory device that modulates mRNA translation. In this form of gene regulation, translation of the CmR coding sequence is prevented by mRNA secondary structure that sequesters its ribosome-binding site (RBS). A translated leader of nine codons precedes the secondary structure, and induction results when a ribosome becomes stalled at a specific site in the leader. Here we demonstrate that the site of ribosome stalling in the leader is selected by a cis effect of the nascent leader peptide on its translating ribosome.

References

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Citations

Jul 16, 2003·Journal of Molecular Biology·Jeffrey L HansenThomas A Steitz
May 15, 2002·FEMS Microbiology Letters·Anthony M George, Ruth M Hall
Dec 5, 2003·Nucleic Acids Research·Katherine S Long, Bo T Porse
Jan 19, 2012·Antimicrobial Agents and Chemotherapy·Ilya A OstermanOlga A Dontsova
Apr 18, 2012·Molecular and Cellular Biology·Jiajie WeiMatthew S Sachs
Aug 19, 2007·Microbial Cell Factories·Louise Carøe Vohlander RasmussenKim Kusk Mortensen
Jan 28, 2009·Molecular Microbiology·Haripriya RamuNora Vazquez-Laslop
Jul 16, 2010·International Journal of Microbiology·Agot AakraIngolf F Nes
Oct 7, 2003·Annual Review of Microbiology·Jeffrey G Lawrence
May 5, 2016·Biomedit︠s︡inskai︠a︡ khimii︠a︡·P V SergievO A Dontsova
May 23, 2009·FEMS Microbiology Letters·Sébastien GalopinRoland Leclercq
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·James MarksAlexander S Mankin
Mar 28, 1998·The Journal of Biological Chemistry·X ZhaoK Palczewski
Jun 16, 2018·Annual Review of Microbiology·Nora Vázquez-Laslop, Alexander S Mankin
Jun 22, 2018·Annual Review of Biochemistry·Junhong ChoiJoseph D Puglisi
Nov 25, 2019·Wiley Interdisciplinary Reviews. RNA·Claude Chiaruttini, Maude Guillier
Feb 2, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Norihisa Noguchi
Oct 24, 2021·Molecular Microbiology·Ju-Hyung LeeJung-Hye Roe

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