Translation initiation of the HIV-1 mRNA

Translation
Théophile OhlmannMarcelo López-Lastra

Abstract

Translation initiation of the full-length mRNA of the human immunodeficiency virus can occur via several different mechanisms to maintain production of viral structural proteins throughout the replication cycle. HIV-1 viral protein synthesis can occur by the use of both a cap-dependant and IRES-driven mechanism depending on the physiological conditions of the cell and the status of the ongoing infection. For both of these mechanisms there is a need for several viral and cellular co-factors for optimal translation of the viral mRNA. In this review we will describe the mechanism used by the full-length mRNA to initiate translation highlighting the role of co-factors within this process. A particular emphasis will be given to the role of the DDX3 RNA helicase in HIV-1 mRNA translation initiation.

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Citations

Dec 6, 2018·Nature Reviews. Microbiology·Zane A Jaafar, Jeffrey S Kieft
Oct 15, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Tiffany A Peterson, Andrew G MacLean
Dec 22, 2020·Frontiers in Microbiology·Pavitra RamdasAjit Chande
Apr 4, 2021·Viruses·Mathilde MalgrasNicolas Lévêque

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