Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory

Drug Discovery Today
Rémy MorgentinAdam Nelson

Abstract

The identification of high-quality starting points for drug discovery is an enduring challenge in medicinal chemistry. Yet, the chemical space explored in discovery programmes tends be limited by the narrow toolkit of robust methods that are exploited in discovery workflows. The European Lead Factory (ELF) was established in 2013 to boost early-stage drug discovery within Europe. In this Feature, we describe an exemplar partnership that has led to the addition of 21119 distinctive screening compounds to the ELF Joint European Compound Library. The partnership could serve as a blueprint for the translation of innovative academic chemistry into discovery programmes.

Citations

Aug 25, 2018·Nature Reviews. Drug Discovery·Jonas BoströmGyörgy M Keserü
Dec 19, 2019·Frontiers in Medicine·Hugh Laverty, Pierre Meulien
Jan 16, 2021·Future Medicinal Chemistry·Ronald W Brown
Apr 24, 2021·Drug Discovery Today·Herman van VlijmenJon S B de Vlieger
Aug 25, 2021·Nature Reviews. Chemistry·Marcus MiethkeRolf Müller
Jan 16, 2020·Organic Letters·James A Rossi-AshtonWilliam P Unsworth

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