Translation of New Molecular Imaging Approaches to the Clinical Setting: Bridging the Gap to Implementation

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Suzanne C van EsElisabeth G E de Vries

Abstract

Molecular imaging with PET is a rapidly emerging technique. In breast cancer patients, more than 45 different PET tracers have been or are presently being tested. With a good rationale, after development of the tracer and proven feasibility, it is of interest to evaluate whether there is a potential meaningful role for the tracer in the clinical setting-such as in staging, in the (early) prediction of a treatment response, or in supporting drug choices. So far, only (18)F-FDG PET has been incorporated into breast cancer guidelines. For proof of the clinical relevance of tracers, especially for analysis in a multicenter setting, standardization of the technology and access to the novel PET tracer are required. However, resources for PET implementation research are limited. Therefore, next to randomized studies, novel approaches are required for proving the clinical value of PET tracers with the smallest possible number of patients. The aim of this review is to describe the process of the development of PET tracers and the level of evidence needed for the use of these tracers in breast cancer. Several breast cancer trials have been performed with the PET tracers (18)F-FDG, 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT), and (18)F-...Continue Reading

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Citations

Aug 20, 2016·Nuclear Medicine and Molecular Imaging·Byeong-Cheol Ahn
Jun 23, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Douglas A Collins
Nov 9, 2019·Journal of Clinical Medicine·Maria Felicia FiordelisiMarco Salvatore

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