Translation regulation of mammalian selenoproteins

Biochimica Et Biophysica Acta. General Subjects
Caroline VindryLaurent Chavatte

Abstract

Interest in selenium research has considerably grown over the last decades owing to the association of selenium deficiencies with an increased risk of several human diseases, including cancers, cardiovascular disorders and infectious diseases. The discovery of a genetically encoded 21st amino acid, selenocysteine, is a fascinating breakthrough in molecular biology as it is the first addition to the genetic code deciphered in the 1960s. Selenocysteine is a structural and functional analog of cysteine, where selenium replaces sulfur, and its presence is critical for the catalytic activity of selenoproteins. The insertion of selenocysteine is a non-canonical translational event, based on the recoding of a UGA codon in selenoprotein mRNAs, normally used as a stop codon in other cellular mRNAs. Two RNA molecules and associated partners are crucial components of the selenocysteine insertion machinery, the Sec-tRNA[Ser]Sec devoted to UGA codon recognition and the SECIS elements located in the 3'UTR of selenoprotein mRNAs. The translational UGA recoding event is a limiting stage of selenoprotein expression and its efficiency is regulated by several factors. The control of selenoproteome expression is crucial for redox homeostasis and a...Continue Reading

Citations

Sep 12, 2018·Chemistry, an Asian Journal·Baoxin ZhangJianguo Fang
Nov 14, 2018·The Journal of Clinical Endocrinology and Metabolism·Chantal ZevenbergenW Edward Visser
Sep 7, 2019·Nutrients·Olivia M GuillinLaurent Chavatte
Jul 25, 2020·Genome Research·Alaaddin Bulak ArpatDavid Gatfield
Nov 14, 2018·Biochemical Society Transactions·Warren P TateChris M Brown
Aug 13, 2020·Cancers·Caroline ChangNadine Hempel
Jan 9, 2021·Biological Trace Element Research·Qin WangZhen-Wu Huang
Feb 19, 2021·Cellular and Molecular Life Sciences : CMLS·David LeitschJulia Walochnik
Oct 16, 2020·Redox Biology·Maria SchwarzAnna Patricia Kipp
Jul 25, 2021·International Journal of Molecular Sciences·Jordan SonetLaurent Chavatte
Dec 7, 2021·Frontiers in Nutrition·Kaitlin DayBarbara R Cardoso

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