Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB).

Biology of Reproduction
Ecem EsencanEmre Seli

Abstract

Transcription ceases upon stimulation of oocyte maturation and gene expression during oocyte maturation, fertilization, and early cleavage relies on translational activation of maternally derived mRNAs. Two key mechanisms that mediate translation of mRNAs in oocytes have been described in detail: cytoplasmic polyadenylation-dependent and -independent. Both of these mechanisms utilize specific protein complexes that interact with cis-acting sequences located on 3'-untranslated region (3'-UTR), and both involve embryonic poly(A) binding protein (EPAB), the predominant poly(A) binding protein during early development. While mechanistic details of these pathways have primarily been elucidated using the Xenopus model, their roles are conserved in mammals and targeted disruption of key regulators in mouse results in female infertility. Here, we provide a detailed account of the molecular mechanisms involved in translational activation during oocyte and early embryo development, and the role of EPAB in this process.

References

Apr 1, 1990·Molecular Reproduction and Development·B A Mattson, D F Albertini
Jun 1, 1971·The Journal of Experimental Zoology·Y Masui, C L Markert
Jan 1, 1995·Molecular Reproduction and Development·A Hampl, J J Eppig
Apr 4, 1995·Biochimica Et Biophysica Acta·E Wahle
Feb 10, 1995·The Journal of Biological Chemistry·E Wahle
May 1, 1994·Human Reproduction·E Y Adashi
Jan 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Gebauer, J D Richter
Feb 6, 1997·Nature·A M SimonD L Paul
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S M FlahertyG M Gilmartin
Nov 20, 1998·Molecular and Cellular Biology·G K Voeltz, J A Steitz
Apr 20, 1999·Biology of Reproduction·S C JunejaG M Kidder
Jan 15, 2000·Molecular Cell·B Stebbins-BoazJ D Richter
Apr 25, 2000·Developmental Biology·J TayJ D Richter
Jan 16, 2004·Developmental Cell·Toshio HamataniMinoru S H Ko
May 18, 2004·Current Opinion in Cell Biology·Nick Proudfoot

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Citations

Apr 23, 2020·Cells·Rozenn Dalbies-TranSvetlana Uzbekova
Apr 9, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Long-Wen Zhao, Heng-Yu Fan
Aug 17, 2021·Frontiers in Cell and Developmental Biology·Yuting XiangXiaoyan Liang
Aug 28, 2021·International Journal of Molecular Sciences·Martin AngerMarketa Charousova

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