Translational applications of flow cytometry in clinical practice

The Journal of Immunology : Official Journal of the American Association of Immunologists
David L JayeEdmund K Waller

Abstract

Flow cytometry has evolved over the past 30 y from a niche laboratory technique to a routine tool used by clinical pathologists and immunologists for diagnosis and monitoring of patients with cancer and immune deficiencies. Identification of novel patterns of expressed Ags has led to the recognition of cancers with unique pathophysiologies and treatment strategies. FACS had permitted the isolation of tumor-free populations of hematopoietic stem cells for cancer patients undergoing stem cell transplantation. Adaptation of flow cytometry to the analysis of multiplex arrays of fluorescent beads that selectively capture proteins and specific DNA sequences has produced highly sensitive and rapid methods for high through-put analysis of cytokines, Abs, and HLA genotypes. Automated data analysis has contributed to the development of a "cytomics" field that integrates cellular physiology, genomics, and proteomics. In this article, we review the impact of the flow cytometer in these areas of medical practice.

References

Jul 1, 1976·European Journal of Immunology·G Köhler, C Milstein
Mar 14, 1969·Science·M A Van DillaJ R Coulter
Jan 15, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·J M VoseJ O Armitage
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul MoretonPeter Hillmen
May 20, 2005·European Journal of Immunology·Giovanna RoncadorAlison H Banham
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Vijay ReddyJohn R Wingard
Sep 26, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David L JayeDan Jones
Aug 2, 2008·Blood·Bruno PaivaUNKNOWN GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) Cooperative Study Grou
Oct 25, 2008·Nature Reviews. Microbiology·David BarnettThomas N Denny
Nov 4, 2008·Current Opinion in Allergy and Clinical Immunology·Joao B OliveiraThomas A Fleisher
Jul 28, 2010·American Journal of Clinical Pathology·Teresa S KrausDavid L Jaye
Dec 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M CeckaM S Leffell
Jul 5, 2011·Methods in Cell Biology·Robert A BrayJar-How Lee
Jul 20, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Antonia M S MüllerJudith A Shizuru

❮ Previous
Next ❯

Citations

Nov 20, 2012·Bioanalysis·Ruth M Barnard
Mar 19, 2014·Cancers·Lori E Lowes, Alison L Allan
Jan 26, 2016·Nature Methods·Andreas P FreiPier Federico Gherardini
Aug 19, 2015·Laboratory Medicine·Ian C Clift
May 18, 2016·BMC Genomics·Maurizio PellegrinoDennis J Eastburn
Mar 24, 2016·International Reviews of Immunology·Ilan VolovitzAttila Tárnok
Dec 20, 2016·Bioconjugate Chemistry·Marta JanczukRobert Hołyst
Apr 21, 2017·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Darina RoitshtainNatan T Shaked
Sep 19, 2012·Cytometry. Part B, Clinical Cytometry·Julie DemaretGuillaume Monneret
Jan 1, 2014·Chembiochem : a European Journal of Chemical Biology·Amy C FlorStephen J Kron
Nov 16, 2016·Nature Communications·Maria Cristina Lo GiudiceKenneth A Dawson
Jun 20, 2014·Critical Care Medicine·Estelle GuérinBruno François
May 5, 2016·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Anders H KvernelandBirgit Sawitzki
Aug 2, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon TurcotteSteven A Rosenberg
Mar 1, 2016·Personalized Medicine·Ralph Snyderman, David Spellmeyer
Mar 21, 2019·International Journal of Molecular Sciences·Sabrina RoyBob S Carter
Jul 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guillaume Monneret, Fabienne Venet
Apr 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Shreyas N DahotreGabriel A Kwong
Jun 6, 2019·World Journal of Emergency Surgery : WJES·Lillian HesselinkFalco Hietbrink
Mar 7, 2020·Neurology. Neuroimmunology and Neuroinflammation·Maria CellerinoAntonio Uccelli
Sep 11, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Noga NissimNatan T Shaked
Nov 13, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Simon TurcotteSteven A Rosenberg
Jun 7, 2018·Analytical Chemistry·Byeongyeon KimSungyoung Choi
Dec 21, 2017·Analytical Chemistry·Takanobu NoboriYoshiki Katayama
Sep 18, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Jue ShiZi-Ning Zhang
Oct 7, 2021·BMC Medicine·Fernando Fernández-BañaresConcepción Núñez

❮ Previous
Next ❯

Related Concepts

Related Feeds

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.

Autoimmune Lymphoproliferative Syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Discover the latest research on ALPS here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

Related Papers

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Guadalupe HerreraJosé-Enrique O'Connor
Molecular & Cellular Proteomics : MCP
Tytus BernasJ Paul Robinson
Cell Vision : the Journal of Analytical Morphology
B H Villas
Cytometry. Part a : the Journal of the International Society for Analytical Cytology
Yoshiharu TokimitsuAtsushi Muraguchi
© 2021 Meta ULC. All rights reserved