Translational breast cancer research: recent advances through the lens of experimental radiotherapy

The Breast : Official Journal of the European Society of Mastology
Jacques Bernier

Abstract

Enormous efforts are currently put forth in translational breast cancer research. These efforts are directed to both the development of new drugs and the implementation of novel techniques of local treatment, including radiotherapy. This latter discipline is actually a particularly fertile ground for translational research, since scientists and clinicians are developing novel tools in biology and radiation physics, which reduce the gap between the lab and the clinic, and identify innovative strategies that one didn't even dream, only a few years ago. Nowadays the most recent advances in translational breast cancer research are articulated, in radiation science, around three main domains, namely molecular biology, experimental models for tumour growth and response to treatment, and mechanisms underlying levels of malignant and normal cell radio-sensitivity/radio-resistance. In an attempt to put into perspective what could be the breast cancer radiotherapy of the next decade, these three domains are reviewed and discussed in the present article, at the light of ongoing, "from bench to bedside" studies.

References

May 11, 2002·Nature Reviews. Cancer·Jos Jonkers, Anton Berns
May 16, 2009·Differentiation; Research in Biological Diversity·Lesley A MathewsW L Farrar
May 28, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bas KreikeMarc J van de Vijver

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Related Papers

Trends in Genetics : TIG
J D Harris, N R Lemoine
Onkologie
Frederik Marmé, Andreas Schneeweiss
American Journal of Clinical Oncology
E J HallN Oleinick
© 2022 Meta ULC. All rights reserved