Translational challenges of animal models in Chagas disease drug development: a review

Drug Design, Development and Therapy
Eric Chatelain, Nandini Konar

Abstract

Chagas disease, or American trypanosomiasis, caused by Trypanosoma cruzi parasite infection is endemic in Latin America and presents an increasing clinical challenge due to migrating populations. Despite being first identified over a century ago, only two drugs are available for its treatment, and recent outcomes from the first clinical trials in 40 years were lackluster. There is a critical need to develop new drugs to treat Chagas disease. This requires a better understanding of the progression of parasite infection, and standardization of animal models designed for Chagas disease drug discovery. Such measures would improve comparison of generated data and the predictability of test hypotheses and models designed for translation to human disease. Existing animal models address both disease pathology and treatment efficacy. Available models have limited predictive value for the preclinical evaluation of novel therapies and need to more confidently predict the efficacy of new drug candidates in clinical trials. This review highlights the overall lack of standardized methodology and assessment tools, which has hampered the development of efficacious compounds to treat Chagas disease. We provide an overview of animal models for C...Continue Reading

Citations

May 25, 2016·International Journal of Antimicrobial Agents·María L SbaragliniCatalina D Alba Soto
Dec 5, 2014·PLoS Neglected Tropical Diseases·Julio Alonso-Padilla, Ana Rodríguez
Sep 18, 2012·Behavioural Brain Research·Judith R Homberg
Feb 25, 2017·Journal of the American College of Cardiology·Caryn Bern
Dec 6, 2017·Antimicrobial Agents and Chemotherapy·A S G NefertitiM N C Soeiro
Aug 17, 2018·Expert Review of Clinical Pharmacology·Jadel Müller KratzSergio Sosa-Estani
Mar 5, 2019·Virulence·Ana Florencia CasassaPatricia Silvia Romano
Jul 19, 2019·Journal of Medical Virology·Xin-Yan HaoHong Gao
Aug 15, 2019·Expert Opinion on Drug Discovery·Fernando Villalta, Girish Rachakonda
Nov 2, 2019·Expert Opinion on Drug Discovery·Alane Beatriz VermelhoClaudiu T Supuran
May 2, 2020·The Journal of Antimicrobial Chemotherapy·Luísa PerinCláudia Martins Carneiro
Jul 9, 2020·Expert Opinion on Investigational Drugs·Nieves Martínez-PeinadoJulio Alonso-Padilla
Aug 11, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Camila Fontes Neves da SilvaSofia Nikolaou
Aug 20, 2020·Expert Opinion on Drug Discovery·Eric Chatelain, Ivan Scandale
Aug 18, 2020·Parasite Immunology·Damián Pérez-MazliahMichael D Lewis
Nov 27, 2018·Oxidative Medicine and Cellular Longevity·Andréa Aparecida Santos MendonçaRômulo Dias Novaes
Aug 21, 2019·Frontiers in Pharmacology·Ana Catarina Cristovão SilvaMarcelo Zaldini Hernandes
Mar 16, 2019·Parasitology·Evaristo Villalba-AlemánReggiani Vilela Gonçalves
Jun 3, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Tatiana Rodrigues AlexandreAndre Gustavo Tempone
Sep 7, 2018·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Beatriz Philot PavãoMaria de Nazaré Correia Soeiro
Jan 1, 2021·Experimental Parasitology·Ludmila Ferreira de Almeida FiuzaMaria de Nazaré Correia Soeiro
Nov 11, 2020·Antimicrobial Agents and Chemotherapy·Suzana Marques de JesusClaudia Martins Carneiro
Dec 22, 2017·Emerging Topics in Life Sciences·Simon L CroftMichael P Barrett
Mar 31, 2021·Journal of Medicinal Chemistry·Jakob BoutonSerge Van Calenbergh
Apr 20, 2021·ACS Infectious Diseases·Rubén Martín-EscolanoClotilde Marín
Jul 3, 2021·Pathogens·Kátia da Silva FonsecaCláudia Martins Carneiro
Jul 3, 2021·Life·Oscar Hernán Rodríguez-BejaranoManuel Alfonso Patarroyo
Jul 17, 2021·Frontiers in Immunology·Fátima FerragutKarina A Gómez
Dec 10, 2020·Canadian Journal of Physiology and Pharmacology·Maiara Voltarelli ProvidelloSérgio de Albuquerque
Jul 28, 2021·PLoS Neglected Tropical Diseases·Gisele Macêdo Rodrigues da CunhaAlexandre Ferreira Marques
Aug 24, 2021·Expert Opinion on Therapeutic Patents·Jabson Herber Profiro de OliveiraJosé Lamartine Soares-Sobrinho

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Methods Mentioned

BETA
imaging techniques
PCR
transgenic

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