PMID: 16629165Apr 25, 2006Paper

Translational control of ceruloplasmin gene expression: beyond the IRE

Biological Research
Barsanjit MazumderPaul L Fox

Abstract

Translational control is a common regulatory mechanism for the expression of iron-related proteins. For example, three enzymes involved in erythrocyte development are regulated by three different control mechanisms: globin synthesis is modulated by heme-regulated translational inhibitor, erythroid 5-aminolevulinate synthase translation is inhibited by binding of the iron regulatory protein to the iron response element in the 5'-untranslated region (UTR); and 15-lipoxygenase is regulated by specific proteins binding to the 3'-UTR. Ceruloplasmin (Cp) is a multi-functional, copper protein made primarily by the liver and by activated macrophages. Cp has important roles in iron homeostasis and in inflammation. Its role in iron metabolism was originally proposed because of its ferroxidase activity and because of its ability to stimulate iron loading into apo-transferrin and iron efflux from liver. We have shown that Cp mRNA is induced by interferon (IFN)-gamma in U937 monocytic cells, but synthesis of Cp protein is halted by translational silencing. The silencing mechanism requires binding of a cytosolic inhibitor complex, IFN-Gamma-Activated Inhibitor of Translation (GAIT), to a specific GAIT element in the Cp 3'-UTR. Here, we descr...Continue Reading

Citations

Jun 1, 2012·Comparative and Functional Genomics·Godfrey Grech, Marieke von Lindern
Nov 15, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·W H Wilson TangStanley L Hazen
Jun 5, 2017·Neurochemistry International·Jeffrey R Liddell, Anthony R White

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