Translational control of putative protooncogene Nm23-M2 by cytokines via phosphoinositide 3-kinase signaling.

The Journal of Biological Chemistry
Marieke JoostenMarieke von Lindern

Abstract

The expansion and differentiation of hematopoietic progenitors is regulated by cytokine and growth factor signaling. To examine how signal transduction controls the gene expression program required for progenitor expansion, we screened ATLAS filters with polysome-associated mRNA derived from erythroid progenitors stimulated with erythropoietin and/or stem cell factor. The putative proto-oncogene nucleoside diphosphate kinase B (ndpk-B or nm23-M2) was identified as an erythropoietin and stem cell factor target gene. Factor-induced expression of nm23-M2 was regulated specifically at the level of polysome association by a phosphoinositide 3-kinase-dependent mechanism. Identification of the transcription initiation site revealed that nm23-M2 mRNA starts with a terminal oligopyrimidine sequence, which is known to render mRNA translation dependent on mitogenic factors. Recently, the nm23-M2 locus was identified as a common leukemia retrovirus integration site, suggesting that it plays a role in leukemia development. The expression of Nm23 from a retroviral vector in the absence of its 5'-untranslated region caused constitutive polysome association of nm23-M2. Polysome-association and protein expression of endogenous nm23-M2 declined ...Continue Reading

References

Apr 6, 1988·Journal of the National Cancer Institute·P S SteegM E Sobel
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·A E WalterM Zuker
Jun 9, 1997·Biochemical and Biophysical Research Communications·W MikulitsE W Müllner
Jan 24, 1998·The Biochemical Journal·C G Proud, R M Denton
Jun 5, 1998·The Journal of Biological Chemistry·R WillemsH Slegers
Apr 27, 1999·The International Journal of Biochemistry & Cell Biology·L McKendrickS J Morley
Dec 2, 1999·Genes & Development·A BauerH Beug
Feb 29, 2000·The Journal of Biological Chemistry·M AokiP K Vogt
Oct 13, 2000·European Journal of Biochemistry·O Meyuhas
Feb 15, 2001·Oncogene·A H Truong, Y Ben-David
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H DolznigE W Müllner
Jul 10, 2002·The Journal of Biological Chemistry·Melanie T HartsoughPatricia S Steeg
Nov 26, 2002·Nature Cell Biology·Felipe PalaciosCrislyn D'Souza-Schorey
Dec 10, 2002·Trends in Molecular Medicine·Cornelis F CalkhovenAchim Leutz
Mar 26, 2003·Clinical & Experimental Metastasis·Massimiliano SalernoPatricia S Steeg
May 17, 2003·Leukemia·N NiitsuUNKNOWN Adult Lymphoma Treatment Study Group
Jan 22, 2004·The Journal of Cell Biology·Walbert J BakkerThamar B van Dijk

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Citations

May 11, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Ram Krishna ThakurShantanu Chowdhury
Apr 22, 2009·Molecular and Cellular Biochemistry·Edith Horn PostelKrista M D La Perle
Apr 5, 2005·Oncogene·Sahar Barjesteh van Waalwijk van Doorn-KhosrovaniRuud Delwel
Apr 15, 2011·The Journal of Biological Chemistry·Dipanjan DuttaMamta Chawla-Sarkar
Apr 7, 2011·Genome Research·Koichiro InakiEdison T Liu
Sep 17, 2005·Molecular and Cellular Biology·Montserrat Blázquez-DomingoMarieke von Lindern
Jun 1, 2012·Comparative and Functional Genomics·Godfrey Grech, Marieke von Lindern
Sep 2, 2010·Biochimica Et Biophysica Acta·Bérengère Pradet-BaladeFlorence Boulmé
May 27, 2015·Biochemical Society Transactions·Klaske A M H Thiadens, Marieke von Lindern
Nov 22, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Yuanjun LiYung H Wong
Sep 2, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lei WangMichael Chopp
Feb 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Edith H PostelKrista M D La Perle
Aug 9, 2018·Frontiers in Physiology·Kat S Moore, Marieke von Lindern

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