Translational informatics in personalized medicine

Personalized Medicine
Eric D Perakslis, John Shon

Abstract

Personalized medicine is often associated and discussed in the context of advances from the human genome project. It is true that significant breakthroughs and advancement of deep sequencing and other analytical technologies have greatly expanded the pool of available biological data, but integrating this data into medically meaningful knowledge via translational informatics remains an area of opportunity that is far from being fully realized. Significant opportunities remain for informatics to drive progress towards wide use and utility of personalized medicine by focusing and exploitation of multimodal biomarkers, precompetitive data sharing and a balance between high-content data and rich phenotypic data, such as real observational medical outcomes.

References

Apr 28, 2001·Trends in Molecular Medicine·B B SpearJ Huff
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jul 20, 2007·The New England Journal of Medicine·David J Hunter, Peter Kraft
Oct 13, 2007·Science·Laura D WoodBert Vogelstein
Jul 3, 2008·The Annals of Pharmacotherapy·Chuenjid KongkaewDarren M Ashcroft
Sep 2, 2008·Journal of Biomedical Informatics·Xiaoming WangOlufunmilayo I Olopade
Sep 6, 2008·Science·Despina G Contopoulos-IoannidisJohn P A Ioannidis
Apr 11, 2009·PLoS Computational Biology·César A HidalgoNicholas A Christakis
Aug 7, 2009·The New England Journal of Medicine·Elaine R MardisTimothy J Ley
Aug 18, 2009·Journal of Biomedical Informatics·Dina Demner-FushmanClement J McDonald
Sep 22, 2009·The American Journal of Geriatric Pharmacotherapy·Julio A LeeyToni P Miles
Oct 10, 2009·Health Policy·Lisa M Meckley, Peter J Neumann
Jan 16, 2010·American Journal of Human Genetics·Rita M CantorJanet S Sinsheimer
Mar 2, 2010·Journal of Translational Medicine·Indra Neil Sarkar
Apr 3, 2010·Nature·Francis Collins
Apr 16, 2010·Nature·UNKNOWN International Cancer Genome ConsortiumHuanming Yang
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Jul 21, 2010·Journal of Translational Medicine·Sándor SzalmaEric D Perakslis
Jul 22, 2010·The New England Journal of Medicine·Teri A Manolio
Sep 25, 2010·Cancer Treatment Reviews·Niels W C J van de DonkAntonio Palumbo
Nov 19, 2010·The New England Journal of Medicine·Hugh Young Rienhoff
Nov 19, 2010·The New England Journal of Medicine·Janardan P Pandey
Dec 1, 2010·Genome Medicine·Elaine R Mardis
Feb 22, 2011·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Anant MadabhushiGeorge Lee
Mar 11, 2011·Nature Biotechnology·Stephen H Friend, Trey Ideker
Mar 11, 2011·Nature Biotechnology·Isaac S Kohane, David M Margulies
May 20, 2011·Nature
Jul 26, 2011·Seminars in Oncology Nursing·William B Lober, Janine L Flowers
Aug 4, 2011·Molecular Genetics and Metabolism·Sean A McGhee
Aug 19, 2011·Science Translational Medicine·Marina SirotaAtul J Butte

❮ Previous
Next ❯

Citations

May 1, 2014·Personalized Medicine·Eric D Perakslis, John Shon
Apr 25, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·B BrüggenjürgenS N Willich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Dental Hygiene
Maria Perno Goldie
Journal of Bioinformatics and Computational Biology
Xing-Ming ZhaoLuonan Chen
Methods of Information in Medicine
H J Seelos
BioMed Research International
Hao-Teng ChangTun-Wen Pai
© 2022 Meta ULC. All rights reserved