Translational medicine--doing it backwards.

Journal of Translational Medicine
Robert B NussenblattAlan N Schechter

Abstract

In recent years the concept of "translational medicine" has been advanced in an attempt to catalyze the medical applications of basic biomedical research. However, there has been little discussion about the readiness of scientists themselves to respond to what we believe is a required new approach to scientific discovery if this new concept is to bear fruit. The present paradigm of hypothesis-driven research poorly suits the needs of biomedical research unless efforts are spent in identifying clinically relevant hypotheses. The dominant funding system favors hypotheses born from model systems and not humans, bypassing the Baconian principle of relevant observations and experimentation before hypotheses. Here, we argue that that this attitude has born two unfortunate results: lack of sufficient rigor in selecting hypotheses relevant to human disease and limitations of most clinical studies to certain outcome parameters rather than expanding knowledge of human pathophysiology; an illogical approach to translational medicine. If we wish to remain true to our responsibility and duty of performing research relevant to human disease, we must begin to think about fundamental new approaches.NIH is the nation's medical research agency--...Continue Reading

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Citations

Aug 30, 2012·Journal of Translational Medicine·Francesco M Marincola, Javaid I Sheikh
Aug 4, 2011·Journal of Translational Medicine·Pierre R SmeestersAndrew C Steer
Jan 6, 2011·Journal of Translational Medicine·Xiangdong WangFrancesco M Marincola
Feb 2, 2013·Clinical and Translational Medicine·Xiangdong Wang, Francesco M Marincola
Feb 8, 2011·Biochemical Pharmacology·Mark DayGerard J Marek
May 18, 2011·Journal of Internal Medicine·Francesco M Marincola
Jul 22, 2010·Annals of the New York Academy of Sciences·Robert B NussenblattUNKNOWN Center for Human Immunology, Autoimmunity and Inflammation, National Institutes of Health
Dec 19, 2014·Chinese Journal of Integrative Medicine·Ji WangQi Wang
Aug 16, 2013·The Journal of Molecular Diagnostics : JMD·Nadine RatertKlaus Jung
Apr 11, 2015·Anais Da Academia Brasileira De Ciências·Meina Li, Lulu Zhang
Aug 11, 2016·Academic Medicine : Journal of the Association of American Medical Colleges·Nicole Edgar FitzpatrickSteven E Reis
Sep 12, 2012·Skin Pharmacology and Physiology·H C KortingM Schäfer-Korting
Nov 30, 2018·The Journal of International Medical Research·Li MeinaZhang Lulu

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Methods Mentioned

BETA
biopsies

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