Translational medicine in hepatocellular carcinoma.

Frontiers of Medicine
Qiang GaoJia Fan

Abstract

Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the molecular stratification of HCCs for diagnosis, prognosis, and therapeutic decision-making. To date, the molecular classification of HCCs has been carried out through transcriptomic, genetic and epigenetic profiling of tumors. Such research has led to identification of several potential molecular targets in HCC, and subsequently, development of novel systemic agents for the treatment of HCC has begun in earnest. In this article, we review the current knowledge of the molecular pathogenesis of HCC and outline potential areas for application of this knowledge in a clinical setting. As a typical virus and inflammation-associated cancer, both host immune response and tumor microenvironment have crucial roles in HCC pathogenesis. In addition, we examine the potential of immunotherapy and strategies targeting various components of the tumor microenvironment, as well as novel molecular and cellular targets in HCC such as can...Continue Reading

References

Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hitoshi YoshijiHiroshi Fukui
Jun 1, 2002·American Journal of Clinical Oncology·Giovannella PalmieriAngelo Martignetti
Jul 20, 2002·Journal of Hepatology·Keiji MinouchiKenichi Kobayashi
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yehuda Z PattLee M Ellis
Mar 6, 2003·Journal of Cancer Research and Clinical Oncology·Lynn G FeunBach Ardalan
Mar 22, 2003·Cancer Immunology, Immunotherapy : CII·Yukio IwashitaSeigo Kitano
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ming KuangTadao Ohno
Jan 15, 2005·Cancer Biotherapy & Radiopharmaceuticals·Shaoliang ChenQingxia Fan
Apr 16, 2005·World Journal of Gastroenterology : WJG·Xiao-Yu YinMing Kuang
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew X ZhuKeith Stuart
May 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa H ButterfieldJames S Economou
May 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Zhi-Nan ChenPing Zhu
Jun 27, 2006·Oncogene·P Laurent-Puig, J Zucman-Rossi
Jul 28, 2006·Cancer Treatment Reviews·Domenico RibattiFranco Dammacco
Oct 19, 2006·Journal of Hepatology·Tim F GretenFirouzeh Korangy
Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincenzo MazzaferroUNKNOWN HCC Italian Task Force
Jan 6, 2007·International Journal of Cancer. Journal International Du Cancer·Shengyong YinJianren Gu
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qiang GaoZhao-You Tang
Jul 12, 2007·Cancer·Melanie B ThomasJames L Abbruzzese
Aug 25, 2007·The Journal of Clinical Investigation·Diego F CalvisiSnorri S Thorgeirsson
Jan 8, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anuradha BudhuXin Wei Wang
Jan 29, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jinmai JiangThomas D Schmittgen
Feb 5, 2008·Cancer Cell·Zhen Fan YangSheung Tat Fan
Mar 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emilia FransveaGianluigi Giannelli
Mar 28, 2008·BMC Cancer·Matthias M DollingerWolfgang E Fleig
May 10, 2008·Journal of Cellular and Molecular Medicine·Hung HuynhEvelyn Tran
May 13, 2008·Journal of Cancer Research and Clinical Oncology·Guo-Ming ShiZhi-Quan Wu
May 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xiao-Dong ZhuHui-Chuan Sun
May 31, 2008·Nature Reviews. Drug Discovery·Paolo M ComoglioLivio Trusolino
Jun 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine E Eyler, Jeremy N Rich
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Jul 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ying-Hong ShiXiao-Ming Yin
Aug 15, 2008·Cancer Research·Derek Y ChiangJosep M Llovet

❮ Previous
Next ❯

Citations

Oct 2, 2014·Journal of Gastroenterology·Kaku Goto, Naoya Kato
Feb 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kejia WangLi Wei
Oct 13, 2015·World Journal of Gastroenterology : WJG·Mitsuro KandaYasuhiro Kodera
Dec 29, 2015·Molecular Medicine Reports·Mi-Hua LiuYuan Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.