Translational metabolomics in cancer research

Biomarkers in Medicine
Nathaniel W SnyderIan A Blair

Abstract

Over the last decade there has been a bottleneck in the introduction of new validated cancer metabolic biomarkers into clinical practice. Unfortunately, there are no biomarkers with adequate sensitivity for the early detection of cancer, and there remain a reliance on cancer antigens for monitoring treatment. The need for new diagnostics has led to the exploration of untargeted metabolomics for discovery of early biomarkers of specific cancers and targeted metabolomics to elucidate mechanistic aspects of tumor progression. The successful translation of such strategies to the treatment of cancer would allow earlier intervention to improve survival. We have reviewed the methodology that is being used to achieve these goals together with recent advances in implementing translational metabolomics in cancer.

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Citations

Jul 30, 2017·Clinical Endocrinology·Chen-Tian ShenQuan-Yong Luo
Jun 9, 2019·Metabolites·Farhana R PinuJacob Jaine
Jun 27, 2020·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O P TrifonovaA I Archakov
Dec 30, 2016·Future Science OA·Ian A BlairMatthew Nunez
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Jun 24, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Peter G ShieldsMark D Wewers
Apr 26, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Alessandro Di MinnoGiuseppe Castaldo
Jan 10, 2018·Journal of Agricultural and Food Chemistry·Yang LuYue Geng

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Methods Mentioned

BETA
metabolomics
NMR
PCA
biopsy
metabolomic profiling
metabolomic
biopsies
metabolomics profiling

Software Mentioned

DA
PLS

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