Translational mini-review series on Th17 cells: CD4 T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation.

Clinical and Experimental Immunology
Richard A O'ConnorStephen M Anderton

Abstract

CD4(+) T cells display considerable flexibility in their effector functions, allowing them to tackle most effectively the range of pathogenic infections with which we are challenged. The classical T helper (Th) 1 and Th2 subsets have been joined recently by the Th17 lineage. If not controlled, the potent effector functions (chiefly cytokine production) of which these different cells are capable can lead to (sometimes fatal) autoimmune and allergic inflammation. The primary cell population tasked with providing this control appears to be CD4(+) regulatory T (T(reg)) cells expressing the forkhead box P3 (FoxP3) transcription factor. Here we consider the comparative capacity of FoxP3(+) T(regs) to influence the polarization, expansion and effector function of Th1, Th2 and Th17 cells in vitro and in vivo as well as in relation to human disease. This remains a particularly challenging series of interactions to understand, especially given our evolving understanding of T(reg) and T effector interrelationships, as well as recent insights into functional plasticity that cast doubt upon the wisdom of a strict categorization of T effector cells based on cytokine production.

References

Jan 1, 1996·European Journal of Immunology·S KanangatM Deheshia
Aug 30, 2001·Nature Immunology·K J Maloy, F Powrie
Oct 9, 2002·The Journal of Experimental Medicine·Yosef RefaeliAbul K Abbas
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adam P KohmStephen D Miller
Jan 8, 2003·The Journal of Experimental Medicine·Kevin J MaloyFiona Powrie
Jan 18, 2003·Science·Chandrashekhar Pasare, Ruslan Medzhitov
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian MottetFiona Powrie
May 15, 2003·Arthritis and Rheumatism·Mary E MorganRené E M Toes
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ludger KleinHarald von Boehmer
Jul 23, 2003·The Journal of Experimental Medicine·Sayuri YamazakiRalph M Steinman
Jul 23, 2003·The Journal of Experimental Medicine·Lucy S K WalkerAbul K Abbas
Aug 29, 2003·Expert Opinion on Biological Therapy·Yasmine Belkaid
Oct 28, 2003·Nature Immunology·Francesca FallarinoPaolo Puccetti
Dec 10, 2003·The Journal of Experimental Medicine·Craig A MurphyDaniel J Cua
Dec 18, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Shuang FuJonathan S Bromberg
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Namita MisraSrini V Kaveri
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ismé M de KleerBerent Prakken
Jun 9, 2004·The Journal of Experimental Medicine·Qizhi TangJeffrey A Bluestone
Jun 9, 2004·The Journal of Experimental Medicine·Kristin V TarbellRalph M Steinman
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael StassenEdgar Schmitt
Jul 29, 2004·The Journal of Experimental Medicine·Michael R EhrensteinClaudia Mauri
Oct 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jayagopala ReddyVijay K Kuchroo
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Mar 9, 2005·The Journal of Experimental Medicine·Linda FahlénFiona Powrie
Mar 23, 2005·Immunity·Jason D FontenotAlexander Y Rudensky
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew D TaylorRick M Maizels
May 5, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·K E EarleJ A Bluestone
Jun 9, 2005·The Journal of Experimental Medicine·Claudia R RuprechtFederica Sallusto
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mandy J McGeachyStephen M Anderton

❮ Previous
Next ❯

Citations

Jul 31, 2010·Transplantation·Stephanie M Coomes, Bethany B Moore
Jan 8, 2014·Nature Reviews. Rheumatology·Tamás KobezdaZoltán Szekanecz
Dec 18, 2012·Immunotherapy·Keiichi MiyamotoTakashi Horiuchi
Dec 24, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M GhafourianN Karami
Dec 16, 2011·The Journal of Allergy and Clinical Immunology·Yvonne VercoulenBerent Prakken
Nov 6, 2012·Clinical and Experimental Immunology·M Peakman
Oct 23, 2010·Clinical and Experimental Immunology·J D M CampbellA Richter
Aug 13, 2015·Pediatric Research·Thomas C MangodtBenedicte Y De Winter
Jan 7, 2011·Clinical Science·Carol PridgeonMargaret J Dallman
Apr 20, 2016·Vaccines·Gonzalo A PradenasAlfredo G Torres
Jul 10, 2010·Current Opinion in Organ Transplantation·Niloufar SafiniaGiovanna Lombardi
Jul 28, 2011·Expert Review of Clinical Immunology·Jocea M R Michels-van AmelsfortLeonie S Taams
May 18, 2017·American Journal of Speech-language Pathology·Billy T OgletreeDavid Westling
Jul 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ismé de KleerBerent Prakken
Dec 18, 2010·Expert Review of Clinical Immunology·Amolak S BansalMeen-Yau Thum
Aug 28, 2020·Frontiers in Immunology·Agnes BonifaciusJochen Huehn
May 13, 2017·International Journal of Oncology·Megumi MaedaTakemi Otsuki
Oct 6, 2016·Experimental and Therapeutic Medicine·Jian-Guo ZhangShu-Juan Jiang
Sep 14, 2020·Parasite Immunology·Zahra NaviAmir Reza Heidari
Nov 30, 2019·Journal of Neuroimmunology·Justin D GlennKatharine A Whartenby

❮ Previous
Next ❯

Related Concepts

Related Feeds