Translational pain research: evaluating analgesic effect in experimental visceral pain models.

World Journal of Gastroenterology : WJG
Anne Estrup OlesenRichard N Upton

Abstract

Deep visceral pain is frequent and presents major challenges in pain management, since its pathophysiology is still poorly understood. One way to optimize treatment of visceral pain is to improve knowledge of the mechanisms behind the pain and the mode of action of analgesic substances. This can be achieved through standardized experimental human pain models. Experimental pain models in healthy volunteers are advantageous for evaluation of analgesic action, as this is often difficult to assess in the clinic because of confounding factors such as sedation, nausea and general malaise. These pain models facilitate minimizing the gap between knowledge gained in animal and human clinical studies. Combining experimental pain studies and pharmacokinetic studies can improve understanding of the pharmacokinetic-pharmacodynamic relationship of analgesics and, thus, provide valuable insight into optimal clinical treatment of visceral pain. To improve treatment of visceral pain, it is important to study the underlying mechanisms of pain and the action of analgesics used for its treatment. An experimental pain model activates different modalities and can be used to investigate the mechanism of action of different analgesics in detail. In co...Continue Reading

References

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Citations

Sep 15, 2012·Bulletin of Experimental Biology and Medicine·L G KolikS B Seredenin
Jan 10, 2009·World Journal of Gastroenterology : WJG·Asbjørn Mohr Drewes, Hans Gregersen
Apr 27, 2010·Neuroscience Letters·Simon VaculinMartin Vejrazka
Feb 19, 2016·Expert Review of Gastroenterology & Hepatology·Adam D FarmerAsbjørn Mohr Drewes
Feb 26, 2014·Current Opinion in Pharmacology·Ann G HayesSimon Tate
Nov 14, 2013·Pain Practice : the Official Journal of World Institute of Pain·Frederik L KristiansenAsbjørn M Drewes
Jun 23, 2012·Pharmacological Reviews·Anne Estrup OlesenAsbjørn Mohr Drewes
Sep 25, 2017·The Journal of Pain : Official Journal of the American Pain Society·Amy K FeehanJames E Zadina

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