Translational potential of olfactory mucosa for the study of neuropsychiatric illness

Translational Psychiatry
K Borgmann-WinterC-G Hahn

Abstract

The olfactory mucosa (OM) is a unique source of regenerative neural tissue that is readily obtainable from living human subjects and thus affords opportunities for the study of psychiatric illnesses. OM tissues can be used, either as ex vivo OM tissue or in vitro OM-derived neural cells, to explore parameters that have been difficult to assess in the brain of living individuals with psychiatric illness. As OM tissues are distinct from brain tissues, an understanding of the neurobiology of the OM is needed to relate findings in these tissues to those of the brain as well as to design and interpret ex vivo or in vitro OM studies. To that end, we discuss the molecular, cellular and functional characteristics of cell types within the olfactory mucosa, describe the organization of the OM and highlight its role in the olfactory neurocircuitry. In addition, we discuss various approaches to in vitro culture of OM-derived cells and their characterization, focusing on the extent to which they reflect the in vivo neurobiology of the OM. Finally, we review studies of ex vivo OM tissues and in vitro OM-derived cells from individuals with psychiatric, neurodegenerative and neurodevelopmental disorders. In particular, we discuss the concordan...Continue Reading

References

Jan 1, 1992·Journal of Molecular Neuroscience : MN·B WolozinH Coon
Jul 1, 1989·Archives of General Psychiatry·S L DubovskyR A Harris
Nov 1, 1994·Neurobiology of Aging·G S JohnsonB Wolozin
Apr 1, 1996·Journal of Neuroscience Research·K P MacDonaldA Mackay-Sim
Nov 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S K Pixley
Jul 1, 1997·The American Journal of Psychiatry·M EmamghoreishiJ J Warsh
Aug 26, 1998·Archives of Otolaryngology--head & Neck Surgery·F FéronA Mackay-Sim
Oct 24, 1998·The Journal of Comparative Neurology·J M HuardJ E Schwob
Jan 23, 1999·American Journal of Medical Genetics·M T AbramsA L Reiss
Oct 28, 1999·Brain Research·F FéronA Mackay-Sim
Dec 5, 2000·Journal of Neuroscience Research·G GomezD Restrepo
Feb 13, 2001·Brain Research·F J RoisenS Maguire
Apr 20, 2001·Nature·D E HanselG V Ronnett
Sep 26, 2001·Archives of General Psychiatry·S E ArnoldC G Hahn
Sep 29, 2001·Brain Research Bulletin·N UranovaV Rachmanova
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cheil MoonGabriele V Ronnett
Aug 31, 2002·Microscopy Research and Technique·Anne L CalofHsiao-Huei Wu
Dec 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Phil Ok KohMichael S Lidow
Jan 28, 2003·Neuron·Hsiao-Huei WuAnne L Calof
Jun 25, 2003·Neuroreport·Toshiaki TsukataniRichard M Costanzo
Aug 2, 2003·Annals of Neurology·Gabriele V RonnettSakkubai Naidu
Mar 18, 2004·Experimental Neurology·Xiaodong ZhangFred J Roisen
Jun 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Junji Hirota, Peter Mombaerts
Jun 25, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lindsay A CarterA Jane Roskams
Sep 29, 2004·The Journal of Comparative Neurology·Glen L ManglapusJames E Schwob
Jan 29, 2005·The Journal of Comparative Neurology·Chang-Gyu HahnSteven E Arnold
Feb 16, 2005·Developmental Neuroscience·Shimako KawauchiAnne L Calof
Feb 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francesca M TheriaultStefano Stifani

❮ Previous
Next ❯

Citations

Sep 17, 2015·Schizophrenia Bulletin·Karin E Borgmann-WinterChang-Gyu Hahn
Feb 9, 2016·Neuroscience·S KálmánK Mirnics
Jan 22, 2017·Trends in Molecular Medicine·Joëlle LavoieKoko Ishizuka
Mar 24, 2017·Current Opinion in Psychiatry·Joëlle LavoieKoko Ishizuka
Oct 6, 2017·Schizophrenia Bulletin·Vidyulata KamathAkira Sawa
Jul 25, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V E GolimbetG Yu Tsarapkin
Apr 3, 2019·Vestnik otorinolaringologii·A I KryukovV E Golimbet
Jan 23, 2020·Cells·Arkadiy K GolovAnd Vera E Golimbet
Feb 15, 2019·Frontiers in Molecular Neuroscience·Alfredo BellonAnne Hosmalin
May 26, 2018·Bulletin of Experimental Biology and Medicine·O V StepanovaV P Chekhonin
Jul 19, 2017·PloS One·Tamara TanosAlicia Rubio
Nov 9, 2017·Advanced Drug Delivery Reviews·Jaclyn Y LockRebecca L Carrier
Jul 4, 2021·The International Journal of Neuropsychopharmacology·Jakob UnterholznerRupert Lanzenberger
Nov 14, 2020·Journal of Proteome Research·Mercedes Lachén-MontesEnrique Santamaría

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
laser capture microdissection
nuclear translocation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Ronald S Duman
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Robert E McCullumsmithJames H Meador-Woodruff
CNS & Neurological Disorders Drug Targets
Jeffrey A Gross, Gustavo Turecki
© 2021 Meta ULC. All rights reserved