Translational Preclinical Pharmacologic Disease Models for Ophthalmic Drug Development

Pharmaceutical Research
Mihir ShahVeena Viswanath

Abstract

Preclinical models of human diseases are critical to our understanding of disease etiology, pathology, and progression and enable the development of effective treatments. An ideal model of human disease should capture anatomical features and pathophysiological mechanisms, mimic the progression pattern, and should be amenable to evaluating translational endpoints and treatment approaches. Preclinical animal models have been developed for a variety of human ophthalmological diseases to mirror disease mechanisms, location of the affected region in the eye and severity. These models offer clues to aid in our fundamental understanding of disease pathogenesis and enable progression of new therapies to clinical development by providing an opportunity to gain proof of concept (POC). Here, we review preclinical animal models associated with development of new therapies for diseases of the ocular surface, glaucoma, presbyopia, and retinal diseases, including diabetic retinopathy and age-related macular degeneration (AMD). We have focused on summarizing the models critical to new drug development and described the translational features of the models that contributed to our understanding of disease pathogenesis and establishment of precli...Continue Reading

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Citations

Apr 17, 2020·International Journal of Molecular Sciences·Céline KosterArthur A Bergen
Oct 25, 2020·Pharmaceutics·Nkiruka IbeanuSahar Awwad
Jan 20, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Amir SadeghiArto Urtti
Jan 29, 2021·International Journal of Molecular Sciences·Nundehui Díaz-LezamaAntje Grosche
Mar 17, 2021·Biomaterials·Alexander E G BakerMolly S Shoichet
Jul 25, 2021·International Journal of Molecular Sciences·Darya V TeleginaNataliya G Kolosova
Jul 5, 2021·Ophthalmology and Therapy·Lixiang WangHui Zhang
Aug 21, 2019·Molecular Pharmaceutics·Mechthild SchmittArto Urtti
Jan 9, 2022·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Sidhartha Sankar HotaSubrata Mallick

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Methods Mentioned

BETA
environmental stress
Transgenic

Clinical Trials Mentioned

NCT00168350

Software Mentioned

Clarivate Analytics Integrity
Parion
Clarivate Analytics
Restasis®
SciFluor

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