PMID: 9531534May 9, 1998Paper

Translational readthrough in the hdc mRNA generates a novel branching inhibitor in the drosophila trachea

Genes & Development
P StenebergC Samakovlis

Abstract

A central question in the development of many branched tubular organs, including the Drosophila trachea, concerns the mechanisms and molecules that control the number and pattern of new branches arising from preexisting vessels. We report on a branching inhibitor, Fusion-6 (Fus-6) produced by specialized tracheal cells to prevent neighboring cells from branching. In Fus-6 mutants, cells that are normally quiescent acquire the branching fate and form an increased number of sprouts emanating from the primary branches. Fus-6 is identified as the headcase (hdc) gene and is expressed in a subset of the cells that extend fusion sprouts to interconnect the tracheal network. hdc expression is regulated by the transcription factor escargot (esg) because it is not expressed in the fusion cells of esg mutants and is ectopically activated in the trachea in response to esg misexpression. We show that the hdc mRNA encodes two overlapping protein products by an unusual suppression of translational termination mechanism. Translational readthrough is necessary for hdc function because rescue of the tracheal mutant phenotype requires the full-length hdc mRNA. In ectopic expression experiments with full-length and truncated hdc constructs, only t...Continue Reading

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Citations

Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E Zelzer, B Z Shilo
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Nov 7, 2000·Current Opinion in Cell Biology·M Affolter, B Z Shilo
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Sep 24, 1999·Mechanisms of Development·P StenebergC Samakovlis
Feb 5, 2004·Molecular Cell·Olivier NamyIan Brierley
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