Translational regulation in nutrigenomics.

Advances in Nutrition
Botao Liu, Shu-Bing Qian

Abstract

The emergence of genome-wide analysis to interrogate cellular DNA, RNA, and protein content has revolutionized the study of the control network that mediates cellular homeostasis. Nutrigenomics addresses the effect of nutrients on gene expression, which provides a basis for understanding the biological activity of dietary components. Translation of mRNAs represents the last step of genetic flow and primarily defines the proteome. Translational regulation is thus critical for gene expression, in particular, under nutrient excess or deficiency. Until recently, it was unclear how the global effects of translational control are influenced by nutrient signaling. An emerging concept of translational reprogramming addresses how to maintain the expression of specific proteins during pathophysiological conditions by translation of selective mRNAs. Here we describe recent advances in our understanding of translational control, nutrient signaling, and their dysregulation in aging and cancer. The mechanistic understanding of translational regulation in response to different nutrient conditions may help identify potential dietary and therapeutic targets to improve human health.

References

Feb 5, 2000·Nature·T V PestovaC U Hellen
Apr 11, 2001·Trends in Biochemical Sciences·B Pradet-BaladeJ A Garcia-Sanz
Aug 13, 2002·Nature Cell Biology·Ken InokiKun-Liang Guan
Aug 13, 2002·Nature Cell Biology·Christopher J PotterTian Xu
Sep 7, 2002·Molecular and Cellular Biology·Peichuan ZhangDouglas R Cavener
Dec 10, 2002·Trends in Molecular Medicine·Cornelis F CalkhovenAchim Leutz
May 27, 2003·Nature Cell Biology·Leslie J SaucedoBruce A Edgar
May 29, 2003·Nature Cell Biology·Yong ZhangDuojia Pan
Jul 19, 2003·Genes & Development·Ken InokiKun-Liang Guan
Dec 12, 2003·Nature·Tibor VellaiFritz Müller
Mar 19, 2004·Nature·Hans-Guido WendelScott W Lowe
Jun 10, 2004·Current Biology : CB·Pankaj KapahiSeymour Benzer
Jul 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Krishna M Vattem, Ronald C Wek
Aug 18, 2004·Molecular and Cellular Biology·Jaime D BlaisJohn C Bell
Oct 2, 2004·Nature Reviews. Molecular Cell Biology·Fátima Gebauer, Matthias W Hentze
Mar 1, 2005·Cell·Leonard Guarente, Frédéric Picard
Jul 14, 2005·Annual Review of Nutrition·M S KilbergV Leung-Pineda
Aug 2, 2005·Trends in Biochemical Sciences·Juan MataJürg Bähler
Jan 19, 2006·Genes & Development·R Wilson PowersStanley Fields
Apr 20, 2006·Experimental Gerontology·Alan R Hipkiss
Jul 20, 2006·The Journal of Biological Chemistry·Daniel ShentonChris M Grant
Feb 3, 2007·Aging Cell·Kally Z PanPankaj Kapahi
Feb 6, 2007·Nature·Popi SyntichakiNektarios Tavernarakis
Apr 17, 2007·Molecular Cell·Daniel H LacknerJürg Bähler
Apr 25, 2007·Mechanisms of Ageing and Development·Alan R Hipkiss
Aug 8, 2007·Nature Reviews. Genetics·Gert C ScheperChristopher G Proud
Sep 6, 2007·The Journal of Clinical Investigation·Jeremy R GraffEric G Marcusson
Oct 25, 2007·Cell·Andrey V PisarevTatyana V Pestova
Dec 7, 2007·Genes & Development·Hans-Guido WendelScott W Lowe
May 8, 2008·Cell Metabolism·Pawan GulatiGeorge Thomas
May 24, 2008·Science·Yasemin SancakDavid M Sabatini
Jul 8, 2008·Nature Cell Biology·Eunjung KimKun-Liang Guan
Jul 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick SchützUlrich Baumann

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Citations

Aug 1, 2015·International Journal of Molecular Sciences·Bodo C Melnik
Nov 28, 2015·Nutrition Reviews·Stephen R Hennigar, James P McClung
Mar 5, 2013·Experimental Gerontology·Ines Sanchez-Roman, Gustavo Barja
Jun 22, 2012·The Proceedings of the Nutrition Society·M J Dauncey
Mar 15, 2014·International Journal of Food Sciences and Nutrition·Betty Schwartz
May 1, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joan M BoylanPhilip A Gruppuso
Feb 8, 2019·Critical Reviews in Food Science and Nutrition·Ayesha NasirSanabil Yaqoob
Mar 4, 2021·Nutrients·Manuela CassottaMaurizio Battino

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